diff --git a/README.md b/README.md new file mode 100644 index 0000000..53d17ad --- /dev/null +++ b/README.md @@ -0,0 +1,23 @@ +# For the paper: + +Brette R. and Gerstner W. (2005), Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity, *J. Neurophysiol.* 94: 3637 - 3642. + +## Abstract: + +We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro. + +A brian simulator model is available at this web page: + +[http://briansimulator.org/docs/examples-frompapers_Brette_Gerstner_2005.html](http://briansimulator.org/docs/examples-frompapers_Brette_Gerstner_2005.html) + +The default setting is the parameters of the regular spiking neuron model in table 1 in the paper (however other settings are available) and generates the following demo figure: + +![screenshot](./screenshot.png) + +This simulation requires Brian which can be downloaded and installed from the instructions available at [http://www.briansimulator.org/](http://www.briansimulator.org/) + +For support on installing and using Brian simulations there is a support group at [https://groups.google.com/group/briansupport](https://groups.google.com/group/briansupport). + +--- + +2025-07-09: Converted README to Markdown. \ No newline at end of file diff --git a/index.html b/index.html deleted file mode 100644 index 31e0d03..0000000 --- a/index.html +++ /dev/null @@ -1,40 +0,0 @@ -
-For the paper:
-
-Brette R. and Gerstner W. (2005), Adaptive Exponential
-Integrate-and-Fire Model as an Effective Description of Neuronal
-Activity, J. Neurophysiol. 94: 3637 - 3642.
-
-Abstract:
-
-We introduce a two-dimensional integrate-and-fire model that combines
-an exponential spike mechanism with an adaptation equation, based on
-recent theoretical findings.  We describe a systematic method to
-estimate its parameters with simple electrophysiological protocols
-(current-clamp injection of pulses and ramps) and apply it to a
-detailed conductance-based model of a regular spiking neuron. Our
-simple model predicts correctly the timing of 96% of the spikes (+/-2
-ms) of the detailed model in response to injection of noisy synaptic
-conductances.  The model is especially reliable in high-conductance
-states, typical of cortical activity in vivo, in which intrinsic
-conductances were found to have a reduced role in shaping spike
-trains. These results are promising because this simple model has
-enough expressive power to reproduce qualitatively several
-electrophysiological classes described in vitro.
-
-A brian simulator model is available at this web page:
-
-http://briansimulator.org/docs/examples-frompapers_Brette_Gerstner_2005.html
-
-The default setting is the parameters of the regular spiking neuron
-model in table 1 in the paper (however other settings are available)
-and generates the following demo figure:
-
-screenshot
-
-This simulation requires Brian which can be downloaded and installed
-from the instructions available at http://www.briansimulator.org/
-
-For support on installing and using Brian simulations there is a
-support group at https://groups.google.com/group/briansupport.
-