diff --git a/index.html b/README.md similarity index 52% rename from index.html rename to README.md index 0cec0c1..bf52752 100644 --- a/index.html +++ b/README.md @@ -1,40 +1,42 @@ -
-For the paper: - -Brette R, Guigon E (2003) Reliability of spike timing is a general -property of spiking model neurons. Neural Comput 15:279-308 - -Abstract: - -The responses of neurons to time-varying injected currents are -reproducible on a trial-by-trial basis in vitro, but when a constant -current is injected, small variances in interspike intervals across -trials add up, eventually leading to a high variance in spike -timing. It is unclear whether this difference is due to the nature of -the input currents or the intrinsic properties of the neurons. Neuron -responses can fail to be reproducible in two ways: dynamical noise can -accumulate over time and lead to a desynchronization over trials, or -several stable responses can exist, depending on the initial -condition. Here we show, through simulations and theoretical -considerations, that for a general class of spiking neuron models, -which includes, in particular, the leaky integrate-and-fire model as -well as nonlinear spiking models, aperiodic currents, contrary to -periodic currents, induce reproducible responses, which are stable -under noise, change in initial conditions and deterministic -perturbations of the input. We provide a theoretical explanation for +## For the paper: + +Brette R, Guigon E (2003) Reliability of spike timing is a general +property of spiking model neurons. *Neural Comput* 15:279-308 + +## Abstract + +The responses of neurons to time-varying injected currents are +reproducible on a trial-by-trial basis in vitro, but when a constant +current is injected, small variances in interspike intervals across +trials add up, eventually leading to a high variance in spike +timing. It is unclear whether this difference is due to the nature of +the input currents or the intrinsic properties of the neurons. Neuron +responses can fail to be reproducible in two ways: dynamical noise can +accumulate over time and lead to a desynchronization over trials, or +several stable responses can exist, depending on the initial +condition. Here we show, through simulations and theoretical +considerations, that for a general class of spiking neuron models, +which includes, in particular, the leaky integrate-and-fire model as +well as nonlinear spiking models, aperiodic currents, contrary to +periodic currents, induce reproducible responses, which are stable +under noise, change in initial conditions and deterministic +perturbations of the input. We provide a theoretical explanation for aperiodic currents that cross the threshold. Brian simulator models are available at this web page: -http://briansimulator.org/docs/examples-frompapers_Brette_Guigon_2003.html +[http://briansimulator.org/docs/examples-frompapers_Brette_Guigon_2003.html](http://briansimulator.org/docs/examples-frompapers_Brette_Guigon_2003.html) The simulation reproduces Fig. 10D,E: -+For support on installing and using Brian simulations there is a +support group at [https://groups.google.com/group/briansupport](https://groups.google.com/group/briansupport). + +--- + +2025-07-09: Converted README to Markdown.+ -This simulation requires Brian which can be downloaded and installed -from the instructions available at http://www.briansimulator.org/ +This simulation requires Brian which can be downloaded and installed +from the instructions available at [http://www.briansimulator.org/](http://www.briansimulator.org/) -For support on installing and using Brian simulations there is a -support group at https://groups.google.com/group/briansupport. -