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<!DOCTYPE html>
<html lang="en">
<head>
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<meta name="robots" content="index, follow" />
<meta name="description" content="Oncko builds experimental and computational systems to discover and optimize multi-drug cancer combinations." />
<meta name="keywords" content="Oncko, oncology, cancer therapeutics, drug combinations, preclinical, machine learning, combination therapy" />
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<title>Oncko | Engineering cancer drug combinations</title>
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</script>
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<link rel="stylesheet" href="css/styles.css">
</head>
<body>
<nav class="side-nav" aria-label="Section navigation">
<a aria-label="Home" class="nav-dot active" data-label="Home" href="#home"><span class="nav-label">Home</span></a>
<a aria-label="Problem" class="nav-dot" data-label="Problem" href="#problem"><span class="nav-label">Problem</span></a>
<a aria-label="Platform" class="nav-dot" data-label="Platform" href="#platform"><span class="nav-label">Platform</span></a>
<a aria-label="Pipeline" class="nav-dot" data-label="Pipeline" href="#pipeline"><span class="nav-label">Pipeline</span></a>
<a aria-label="Team" class="nav-dot" data-label="Team" href="#team"><span class="nav-label">Team</span></a>
<a aria-label="Advisors" class="nav-dot" data-label="Advisors" href="#advisors"><span class="nav-label">Advisors</span></a>
<a aria-label="Contact" class="nav-dot" data-label="Contact" href="#contact"><span class="nav-label">Contact</span></a>
</nav>
<header class="site-header">
<img src="img/ONCKO-LOGO.svg" alt="Oncko" class="logo">
</header>
<main class="shell">
<section class="section section-reveal" id="home" data-nav="0">
<div class="container hero-grid">
<div>
<div class="eyebrow reveal">Combination intelligence</div>
<h1 class="reveal-up reveal-delay-1">Engineering cancer drug combinations.</h1>
<p class="lede reveal-up reveal-delay-2">
Cancer evolves resistance quickly.
<br>The most effective treatments are often combinations of drugs.
<br>But choosing the right drugs, doses, and schedules is hard.
<br>Our name, Oncko, reflects our mission to solve this search problem in oncology — the combinatorial challenge known as <a href="https://en.wikipedia.org/wiki/Binomial_coefficient" rel="noopener noreferrer"><strong>nCk</strong></a>.
</p>
</div>
<div>
<div class="hero-orb reveal-scale reveal-delay-2" aria-hidden="true">
<div class="hero-logo-wrap">
<img src="img/ONCKO-ICON.png" alt="" class="hero-logo-mark">
</div>
</div>
</div>
</div>
</section>
<section class="section section-reveal" id="problem" data-nav="1">
<div class="container problem-grid">
<div>
<div class="eyebrow reveal">Problem</div>
<h2 class="reveal-up">Combos work</h2>
<p></p>
<div class="stat-grid">
<div class="card stat reveal-up reveal-delay-1">
<div class="kicker">Lung</div>
<div class="value">2-drug</div>
<p>Platinum doublet</p>
</div>
<div class="card stat reveal-up reveal-delay-2">
<div class="kicker">Testicular</div>
<div class="value">3-drug</div>
<p>BEP</p>
</div>
<div class="card stat">
<div class="kicker">Colorectal</div>
<div class="value">4-drug</div>
<p>FOLFOXIRI</p>
</div>
<div class="card stat reveal-up reveal-delay-3">
<div class="kicker">Myeloma</div>
<div class="value">4-drug</div>
<p>D-VRd</p>
</div>
<div class="card stat">
<div class="kicker">Lymphoma</div>
<div class="value">5-drug</div>
<p>R-CHOP</p>
</div>
<div class="card stat reveal-up reveal-delay-4">
<div class="kicker">Pediatric ALL</div>
<div class="value">8-drug</div>
<p>Various regimens</p>
</div>
</div>
</div>
<div>
<h2 class="reveal reveal-delay-1">(10<sup>5</sup>-10<sup>15</sup>) search</h2>
<p>The table below illustrates the challenge of discovering multi-drug combinations from 100 candidate drugs—selecting the right drugs, doses, and schedules.
<br><br></p>
<table class="pipeline-table reveal-up reveal-delay-1" aria-label="Combination search space">
<thead>
<tr>
<th>Drugs / combo</th>
<th>Drug combinations</th>
<th>+ dose & schedule</th>
</tr>
</thead>
<tbody>
<tr>
<td data-label="Combination size">2-drug</td>
<td data-label="Drug combos">~5k</td>
<td data-label="Dose schedule">~160k</td>
</tr>
<tr>
<td data-label="Combination size">4-drug</td>
<td data-label="Drug combos">~3.9M</td>
<td data-label="Dose schedule">~4B</td>
</tr>
<tr>
<td data-label="Combination size">8-drug</td>
<td data-label="Drug combos">~186B</td>
<td data-label="Dose schedule">~6Q</td>
</tr>
</tbody>
</table>
</div>
</div>
</section>
<section class="section section-reveal" id="platform" data-nav="2">
<div class="container solve-grid">
<div class="platform-copy">
<div class="eyebrow reveal">How we solve it</div>
<h2 class="reveal-up">Discovery & optimization.</h2>
<p class="lede reveal reveal-delay-1" style="max-width: 48ch;"></p>
<div class="bullet-list">
<div class="card bullet-item reveal-left reveal-delay-1">
<div class="bullet-index">01</div>
<div>
<h3>Screen against SuperTumor™</h3>
<p>Combos are tested in SuperTumor™, an experimental model that represents 1 million cancer resistance mechanisms.</p>
</div>
</div>
<div class="card bullet-item reveal-left reveal-delay-2">
<div class="bullet-index">02</div>
<div>
<h3>Quantify efficacy and toxicity</h3>
<p>Combos are tested in vivo and in silico leveraging real-world patient data.</p>
</div>
</div>
<div class="card bullet-item reveal-left reveal-delay-3">
<div class="bullet-index">03</div>
<div>
<h3>Optimize therapeutic index</h3>
<p>Search toward combinations with improved activity and lower expected toxicity.</p>
</div>
</div>
</div>
</div>
<div class="card viz-shell reveal-right">
<section class="viz">
<svg id="scene" viewBox="0 0 600 400" aria-label="Biotech drug combination animation">
<defs>
<radialGradient id="goldOrb" cx="50%" cy="50%" r="50%">
<stop offset="0%" stop-color="rgba(255,248,214,1)" />
<stop offset="42%" stop-color="rgba(255,219,108,0.98)" />
<stop offset="78%" stop-color="rgba(255,184,77,0.82)" />
<stop offset="100%" stop-color="rgba(255,184,77,0.08)" />
</radialGradient>
<linearGradient id="lineGrad" x1="0%" y1="0%" x2="100%" y2="0%">
<stop offset="0%" stop-color="rgba(111,231,255,0.0)" />
<stop offset="50%" stop-color="rgba(111,231,255,0.48)" />
<stop offset="100%" stop-color="rgba(255,212,95,0.55)" />
</linearGradient>
<filter id="softGlow">
<feGaussianBlur stdDeviation="8" result="blur"></feGaussianBlur>
<feMerge>
<feMergeNode in="blur"></feMergeNode>
<feMergeNode in="SourceGraphic"></feMergeNode>
</feMerge>
</filter>
</defs>
<g id="stars"></g>
<g id="lines"></g>
<g id="drugs"></g>
<g id="orbLayer">
<circle id="orbHalo" cx="380" cy="165" r="58" fill="rgba(255,209,102,0.08)" filter="url(#softGlow)" opacity="0.08"></circle>
<circle id="orbOuter" cx="380" cy="165" r="34" fill="url(#goldOrb)" filter="url(#softGlow)" opacity="0.08"></circle>
<circle id="orbInner" cx="380" cy="165" r="18" fill="rgba(255,245,210,0.98)" opacity="0.06"></circle>
<image id="orbLogo" href="img/ONCKO-ICON.png" x="326" y="111" width="108" height="108" opacity="0.0" preserveAspectRatio="xMidYMid meet"></image>
</g>
</svg>
<div class="tag">Discover combo partners → optimize regimen</div>
<div class="score-panel" id="scorePanel">
<div class="score-stage" id="scoreStage">Search initialized</div>
<div class="score-sub" id="scoreSub">Selecting an initial multi-drug regimen</div>
<div class="score-metrics">
<div class="score-metric">
<div class="score-metric-label">Efficacy</div>
<div class="bar"><div class="fill eff" id="simEffFill"></div></div>
<div class="score-metric-value" id="simEffValue">0</div>
</div>
<div class="score-metric">
<div class="score-metric-label">Toxicity</div>
<div class="bar"><div class="fill tox" id="simToxFill"></div></div>
<div class="score-metric-value" id="simToxValue">0</div>
</div>
</div>
</div>
</section>
</div>
</div>
</section>
<section class="section section-reveal" id="pipeline" data-nav="3">
<div class="container pipeline-wrap">
<div>
<div class="eyebrow reveal">Pipeline</div>
<h2 class="reveal-up">Our novel multi-drug combos.</h2>
<p class="lede" style="max-width: 42ch;"></p>
</div>
<div>
<table class="pipeline-table reveal-up reveal-delay-1" aria-label="Pipeline table">
<thead>
<tr>
<th>Program</th>
<th>Indication</th>
<th>Focus</th>
<th>In vivo efficacy</th>
<th>Stage</th>
</tr>
</thead>
<tbody>
<tr>
<td data-label="Program">Combo #1</td>
<td data-label="Indication">2L NSCLC</td>
<td data-label="Focus">4-drug, orthogonal mechanisms</td>
<td data-label="InVivo">✓</td>
<td data-label="Stage"><span class="stage-pill">Preclinical</span></td>
</tr>
<tr>
<td data-label="Program">Discovery campaign #2</td>
<td data-label="Indication">2L NSCLC</td>
<td data-label="Focus">Resistance-targeting regimens</td>
<td data-label="InVivo"></td>
<td data-label="Stage"><span class="stage-pill">Discovery</span></td>
</tr>
<tr>
<td data-label="Program">Discovery campaign #3</td>
<td data-label="Indication">2L CRC</td>
<td data-label="Focus">Resistance-targeting regimens</td>
<td data-label="InVivo"></td>
<td data-label="Stage"><span class="stage-pill">Discovery</span></td>
</tr>
</tbody>
</table>
</div>
</div>
</section>
<section class="section section-reveal" id="team" data-nav="4">
<div class="container">
<div class="eyebrow reveal">Team</div>
<h2>Built by scientists and operators who know combinations.</h2>
<p class="lede reveal reveal-delay-1" style="max-width: 56ch; margin-bottom: 28px;">
Oncko brings together expertise in cancer therapeutics, large-scale experimental platforms, and machine learning.
</p>
<div class="team-grid">
<a href="https://www.linkedin.com/in/atray-dixit/" target="_blank" rel="noopener noreferrer" aria-label="Atray Dixit on LinkedIn" class="card team-card team-link reveal-up reveal-delay-1">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/atray.jpg" alt="Atray Dixit" loading="lazy" />
</div>
<h3>Atray Dixit</h3>
<div class="team-role">Co-founder, CEO</div>
<p>Inventor of Perturb-seq and co-developer of Shuffle-seq, building scalable discovery systems for combination therapeutics.</p>
</a>
<a href="https://www.linkedin.com/in/tim-sproul/" target="_blank" rel="noopener noreferrer" aria-label="Tim Sproul on LinkedIn" class="card team-card team-link reveal-up reveal-delay-2">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/tim.jpg" alt="Tim Sproul" loading="lazy" />
</div>
<h3>Tim Sproul</h3>
<div class="team-role">Head of Preclinical</div>
<p>Leads preclinical strategy and translational execution across Oncko’s multi-drug combination programs.</p>
</a>
<a href="https://www.linkedin.com/in/glenn-wozniak-00520511/" target="_blank" rel="noopener noreferrer" aria-label="Glenn Wozniak on LinkedIn" class="card team-card team-link reveal-up reveal-delay-3">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/glenn.jpg" alt="Glenn Wozniak" loading="lazy" />
</div>
<h3>Glenn Wozniak</h3>
<div class="team-role">Principal Scientist</div>
<p>Principal scientist focused on experimental rigor, combination screening, and platform development.</p>
</a>
<a href="https://linkedin.com/in/andresmanas/" target="_blank" rel="noopener noreferrer" aria-label="Andrés Mañas on LinkedIn" class="card team-card team-link reveal-up reveal-delay-4">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/andres.jpg" alt="Andrés Mañas" loading="lazy" />
</div>
<h3>Andrés Mañas</h3>
<div class="team-role">AI Engineer</div>
<p>AI engineer developing the models and infrastructure that connect experimental signal to regimen optimization.</p>
</a>
<a href="https://www.linkedin.com/in/madinah-n-030724146/" target="_blank" rel="noopener noreferrer" aria-label="Madinah Najib on LinkedIn" class="card team-card team-link reveal-up reveal-delay-4">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/madinah.jpg" alt="Madinah Najib" loading="lazy" />
</div>
<h3>Madinah Najib</h3>
<div class="team-role">Senior Research Associate</div>
<p>Senior research associate driving assay execution and high-quality data generation across discovery campaigns.</p>
</a>
</div>
</div>
</section>
<section class="section section-reveal" id="advisors" data-nav="5">
<div class="container">
<div class="eyebrow reveal">Advisors</div>
<h2 class="reveal-up">Supported by a world-class advising team</h2>
<p class="lede" style="max-width: 56ch; margin-bottom: 28px;"></p>
<div class="team-grid">
<a href="https://www.linkedin.com/in/william-grossman-md-phd-7958018/" target="_blank" rel="noopener noreferrer" aria-label="Bill Grossman on LinkedIn" class="card team-card team-link reveal-up reveal-delay-1">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/bill.jpg" alt="Bill Grossman" loading="lazy" />
</div>
<h3>Bill Grossman</h3>
<div class="team-role">Co-founder, Strategic Advisor</div>
<p>Oncology drug development leader who has developed cancer combos through clinical trials, including senior leadership roles at Arcus Biosciences and Gilead.</p>
</a>
<a href="https://www.linkedin.com/in/alice-shaw-7a1023b/" target="_blank" rel="noopener noreferrer" aria-label="Alice Shaw on LinkedIn" class="card team-card team-link reveal-up reveal-delay-2">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/alice.jpg" alt="Alice Shaw" loading="lazy" />
</div>
<h3>Alice Shaw</h3>
<div class="team-role">Chair, Department of Medical Oncology, DFCI</div>
<p>An expert in clinical NSCLC and drug resistance. Dr. Shaw was previously vice president and global head of translational clinical oncology at Novartis for almost five years.</p>
</a>
<a href="https://www.linkedin.com/in/adam-palmer-02181814/" target="_blank" rel="noopener noreferrer" aria-label="Adam Palmer on LinkedIn" class="card team-card team-link reveal-up reveal-delay-3">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/adam.jpg" alt="Adam Palmer" loading="lazy" />
</div>
<h3>Adam Palmer</h3>
<div class="team-role">Professor, UNC</div>
<p>Demonstrated independent drug action explains a large portion of successful cancer combinations and showed a roadmap to designing better ones.</p>
</a>
<a href="https://www.linkedin.com/in/luke-gilbert-482a1048/" target="_blank" rel="noopener noreferrer" aria-label="Luke Gilbert on LinkedIn" class="card team-card team-link reveal-up reveal-delay-4">
<div class="team-link-badge"><i class="fa fa-linkedin-square" style="font-size:30px"></i></div>
<div class="team-photo">
<img src="img/team/luke.jpg" alt="Luke Gilbert" loading="lazy" />
</div>
<h3>Luke Gilbert</h3>
<div class="team-role">Professor, Arc Institute</div>
<p>Cancer biology and combination CRISPR screening expert.</p>
</a>
</div>
</div>
</section>
<section class="section" id="contact" data-nav="6">
<div class="container contact-grid">
<div>
<div class="eyebrow reveal">Contact</div>
<h2 class="reveal-up">Let’s talk.</h2>
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