diff --git a/Makefile b/Makefile
index 89a25b1a..549a9005 100644
--- a/Makefile
+++ b/Makefile
@@ -23,6 +23,9 @@ GO     := go
 GOPATH ?= $(firstword $(subst :, ,$(shell $(GO) env GOPATH)))
 PROMU  := $(GOPATH)/bin/promu
 PROMU_VERSION := v0.17.0
+YQ  := $(GOPATH)/bin/yq
+YQ_VERSION  := v4.52.4
+
 pkgs    = $(shell $(GO) list ./... | grep -v /vendor/)
 
 PREFIX              ?= $(shell pwd)
@@ -53,6 +56,13 @@ build: promu
 	@echo ">> building binaries"
 	@$(PROMU) build --prefix $(PREFIX)
 
+build-nomysql: yq promu
+	@echo ">> building binaries with -tag nomysql"
+	@echo ">> updating build tags to include 'nomysql'"
+	@$(YQ) eval '.build |= (.flags += ",nomysql")' .promu.yml > .promu_nomysql.yml
+	@$(PROMU) build --prefix $(PREFIX) --config .promu_nomysql.yml
+	@rm .promu_nomysql.yml
+
 drivers-%:
 	@echo ">> generating drivers.go with selected drivers"
 	@$(GO) run drivers_gen.go -- $*
@@ -87,11 +97,19 @@ promu:
 	@set GOOS=windows
 	@set GOARCH=$(subst AMD64,amd64,$(patsubst i%86,386,$(shell echo %PROCESSOR_ARCHITECTURE%)))
 	@$(GO) install github.com/prometheus/promu@$(PROMU_VERSION)
+yq:
+	@set GOOS=windows
+	@set GOARCH=$(subst AMD64,amd64,$(patsubst i%86,386,$(shell echo %PROCESSOR_ARCHITECTURE%)))
+		$(GO) install github.com/mikefarah/yq/v4@$(YQ_VERSION)
 else
 promu:
 	@GOOS=$(shell uname -s | tr A-Z a-z) \
 		GOARCH=$(subst x86_64,amd64,$(patsubst i%86,386,$(shell uname -m))) \
 		$(GO) install github.com/prometheus/promu@$(PROMU_VERSION)
+yq:
+	@GOOS=$(shell uname -s | tr A-Z a-z) \
+		GOARCH=$(subst x86_64,amd64,$(patsubst i%86,386,$(shell uname -m))) \
+		$(GO) install github.com/mikefarah/yq/v4@$(YQ_VERSION)
 endif
 
 .PHONY: all style format build test vet tarball docker promu
diff --git a/README.md b/README.md
index 61e1aa56..4e910964 100644
--- a/README.md
+++ b/README.md
@@ -432,6 +432,35 @@ The format of the file is described in the
 [exporter-toolkit](https://github.com/prometheus/exporter-toolkit/blob/master/docs/web-configuration.md) repository.
 </details>
 
+<details>
+<summary>MySQL Custom TLS Certificate Support</summary>
+
+Since v0.20.0 SQL Exporter supports custom TLS certificates for MySQL connections. This is useful when you have a
+self-signed certificate, a certificate from a private CA, or want to use mTLS for MySQL connections.
+
+To use custom TLS certificates for MySQL connections, you need to add the following parameters to the DSN:
+
+1. `tls=custom` to indicate that you want to use a custom TLS configuration (required to enable custom TLS support);
+2. `tls-ca=<PATH_TO_CA_CERT>` to specify the path to the CA certificate file (if your certificate is self-signed or
+   from a private CA);
+3. `tls-cert=<PATH_TO_CLIENT_CERT>` and `tls-key=<PATH_TO_CLIENT_KEY>` to specify the paths to the client certificate
+   and key files if you want to use mTLS (if your MySQL server requires client authentication).
+
+The DSN would look like this:
+```
+mysql://user:password@hostname:port/dbname?tls=custom&tls-ca=/path/to/ca.pem
+mysql://user:password@hostname:port/dbname?tls=custom&tls-cert=/path/to/client-cert.pem&tls-key=/path/to/client-key.pem
+```
+
+This configuration is only applied to MySQL as there is no way to provide the configuration natively. For other
+databases, you may want to consult their documentation on how to set up TLS connections and apply the necessary
+parameters to the DSN if it's supported by the driver.
+
+TLS Configuration is bound to the hostname+port combinations, so if there are connections using the same hostname+port
+combination, they will share and re-use the same TLS configuration.
+</details>
+
+## Support
 
 If you have an issue using sql_exporter, please check [Discussions](https://github.com/burningalchemist/sql_exporter/discussions) or
 closed [Issues](https://github.com/burningalchemist/sql_exporter/issues?q=is%3Aissue+is%3Aclosed) first. Chances are
diff --git a/sql.go b/sql.go
index 77aac03b..a5d461a0 100644
--- a/sql.go
+++ b/sql.go
@@ -3,6 +3,7 @@ package sql_exporter
 import (
 	"context"
 	"database/sql"
+	"encoding/base64"
 	"errors"
 	"fmt"
 	"log/slog"
@@ -33,6 +34,38 @@ func OpenConnection(ctx context.Context, logContext, dsn string, maxConns, maxId
 		driver = url.GoDriver
 	}
 
+	// Register custom TLS config for MySQL if needed
+	if driver == "mysql" && url.Query().Get("tls") == "custom" {
+
+		// Encode the hostname and port to create a unique name for the TLS configuration. This ensures that different
+		// DSNs with the same TLS parameters will reuse the same TLS configuration.
+		configName := "custom-" + base64.URLEncoding.WithPadding(base64.NoPadding).
+			EncodeToString([]byte(url.Hostname()+url.Port()))
+
+		if err := handleMySQLTLSConfig(configName, url.Query()); err != nil {
+			return nil,
+				fmt.Errorf("failed to register MySQL TLS config: %w", err)
+		}
+
+		// Strip TLS parameters from the URL as they are interpreted as system variables by the MySQL driver which
+		// causes connection failure. The TLS configuration is already registered globally.
+		q := url.Query()
+		for _, param := range mysqlTLSParams {
+			q.Del(param)
+		}
+
+		// Set the "tls" parameter to the unique name of the registered TLS configuration.
+		q.Set("tls", configName)
+		url.RawQuery = q.Encode()
+
+		// Regenerate the DSN without TLS parameters for logging and connection purposes
+		tlsStripped, _, err := dburl.GenMysql(url)
+		if err != nil {
+			return nil, fmt.Errorf("failed to generate MySQL DSN: %w", err)
+		}
+		url.DSN = tlsStripped
+	}
+
 	// Open the DB handle in a separate goroutine so we can terminate early if the context closes.
 	go func() {
 		conn, err = sql.Open(driver, url.DSN)
diff --git a/tls_mysql.go b/tls_mysql.go
new file mode 100644
index 00000000..a926f3cf
--- /dev/null
+++ b/tls_mysql.go
@@ -0,0 +1,89 @@
+//go:build !nomysql
+
+package sql_exporter
+
+import (
+	"crypto/tls"
+	"crypto/x509"
+	"errors"
+	"fmt"
+	"log/slog"
+	"net/url"
+	"os"
+	"sync"
+
+	"github.com/go-sql-driver/mysql"
+)
+
+const (
+	mysqlTLSParamCACert     = "tls-ca"
+	mysqlTLSParamClientCert = "tls-cert"
+	mysqlTLSParamClientKey  = "tls-key"
+)
+
+// mysqlTLSParams is a list of TLS parameters that can be used in MySQL DSNs. It is used to identify and strip TLS
+// parameters from the DSN after registering the TLS configuration, as these parameters are not recognized by the MySQL
+// driver and would cause connection failure if left in the DSN.
+var (
+	mysqlTLSParams = []string{mysqlTLSParamCACert, mysqlTLSParamClientCert, mysqlTLSParamClientKey}
+
+	onceMap sync.Map
+)
+
+// handleMySQLTLSConfig wraps the registration of a MySQL TLS configuration in a thread-safe manner. It uses a
+// sync.Once to ensure that the TLS configuration for a given config name is registered only once, even if multiple
+// goroutines attempt to register it concurrently.
+func handleMySQLTLSConfig(configName string, params url.Values) error {
+	onceConn, _ := onceMap.LoadOrStore(configName, &sync.Once{})
+	once := onceConn.(*sync.Once)
+	var err error
+	once.Do(func() {
+		err = registerMySQLTLSConfig(configName, params)
+		if err != nil {
+			slog.Error("Failed to register MySQL TLS config", "error", err)
+		}
+	})
+	return err
+}
+
+// registerMySQLTLSConfig registers a custom TLS configuration for MySQL with the given config name and parameters.
+func registerMySQLTLSConfig(configName string, params url.Values) error {
+	caCert := params.Get(mysqlTLSParamCACert)
+	clientCert := params.Get(mysqlTLSParamClientCert)
+	clientKey := params.Get(mysqlTLSParamClientKey)
+
+	slog.Debug("MySQL TLS config", "configName", configName, mysqlTLSParamCACert, caCert,
+		mysqlTLSParamClientCert, clientCert, mysqlTLSParamClientKey, clientKey)
+
+	var rootCertPool *x509.CertPool
+	if caCert != "" {
+		rootCertPool = x509.NewCertPool()
+		pem, err := os.ReadFile(caCert)
+		if err != nil {
+			return fmt.Errorf("failed to read CA certificate: %w", err)
+		}
+		if ok := rootCertPool.AppendCertsFromPEM(pem); !ok {
+			return errors.New("failed to append PEM")
+		}
+	}
+
+	var certs []tls.Certificate
+	if clientCert != "" || clientKey != "" {
+		if clientCert == "" || clientKey == "" {
+			return errors.New("both tls-cert and tls-key must be provided for client authentication")
+		}
+		cert, err := tls.LoadX509KeyPair(clientCert, clientKey)
+		if err != nil {
+			return fmt.Errorf("failed to load client certificate and key: %w", err)
+		}
+		certs = append(certs, cert)
+	}
+
+	tlsConfig := &tls.Config{
+		RootCAs:      rootCertPool,
+		Certificates: certs,
+		MinVersion:   tls.VersionTLS12,
+	}
+
+	return mysql.RegisterTLSConfig(configName, tlsConfig)
+}
diff --git a/tls_nomysql.go b/tls_nomysql.go
new file mode 100644
index 00000000..05cdacdc
--- /dev/null
+++ b/tls_nomysql.go
@@ -0,0 +1,16 @@
+//go:build nomysql
+
+package sql_exporter
+
+import (
+	"errors"
+	"net/url"
+)
+
+// There are no TLS parameters to strip when MySQL support is disabled, but we need to define the variable to avoid compilation errors in sql.go.
+var mysqlTLSParams = []string{}
+
+// registerMySQLTLSConfig is a stub function that returns an error indicating that MySQL TLS support is disabled when the "nomysql" build tag is used.
+func handleMySQLTLSConfig(_ url.Values) error {
+	return errors.New("MySQL TLS support disabled (built with -tags nomysql)")
+}