diff --git a/src/libraries/Microsoft.Extensions.Caching.Memory/src/MemoryCache.cs b/src/libraries/Microsoft.Extensions.Caching.Memory/src/MemoryCache.cs
index 51b5c3fe523e64..2c21f411b32fdd 100644
--- a/src/libraries/Microsoft.Extensions.Caching.Memory/src/MemoryCache.cs
+++ b/src/libraries/Microsoft.Extensions.Caching.Memory/src/MemoryCache.cs
@@ -186,8 +186,8 @@ internal void SetEntry(CacheEntry entry)
                             // exactly once, tied to the swap we performed. Doing this speculatively
                             // inside UpdateCacheSizeExceedsCapacity (before the swap) races with a
                             // concurrent RemoveEntry of the prior entry and double-counts the decrement,
-                            // drifting _cacheSize negative and permanently blocking all future inserts.
-                            Interlocked.Add(ref coherentState._cacheSize, -priorEntry.Size);
+                            // drifting CacheSize negative and permanently blocking all future inserts.
+                            Interlocked.Add(ref coherentState.CacheSize, -priorEntry.Size);
                         }
                     }
                     else
@@ -209,7 +209,7 @@ internal void SetEntry(CacheEntry entry)
                     if (_options.HasSizeLimit)
                     {
                         // Entry could not be added, roll back the size increment for this entry only.
-                        Interlocked.Add(ref coherentState._cacheSize, -entry.Size);
+                        Interlocked.Add(ref coherentState.CacheSize, -entry.Size);
                     }
                     entry.SetExpired(EvictionReason.Replaced);
                     entry.InvokeEvictionCallbacks();
@@ -361,7 +361,7 @@ public void Remove(object key)
             {
                 if (_options.HasSizeLimit)
                 {
-                    Interlocked.Add(ref coherentState._cacheSize, -entry.Size);
+                    Interlocked.Add(ref coherentState.CacheSize, -entry.Size);
                 }
 
                 entry.SetExpired(EvictionReason.Removed);
@@ -554,11 +554,11 @@ private bool UpdateCacheSizeExceedsCapacity(CacheEntry entry, CacheEntry? priorE
             {
                 // The capacity decision still accounts for the prior entry being replaced (its size is
                 // freed by the replace), so a same-or-smaller replacement at the size limit is admitted.
-                // However, only the new entry's size is committed to _cacheSize here. The prior entry's
+                // However, only the new entry's size is committed to CacheSize here. The prior entry's
                 // size is decremented by the caller, atomically with the dictionary swap that actually
                 // removes it. Decrementing the prior size here (before the swap) races with a concurrent
                 // RemoveEntry of the same prior entry and double-counts the decrement, drifting
-                // _cacheSize negative and permanently blocking all future inserts.
+                // CacheSize negative and permanently blocking all future inserts.
                 long sizeAfterReplace = sizeRead + entry.Size - priorSize;
 
                 if ((ulong)sizeAfterReplace > (ulong)sizeLimit)
@@ -568,7 +568,7 @@ private bool UpdateCacheSizeExceedsCapacity(CacheEntry entry, CacheEntry? priorE
                 }
 
                 long committedSize = sizeRead + entry.Size;
-                long original = Interlocked.CompareExchange(ref coherentState._cacheSize, committedSize, sizeRead);
+                long original = Interlocked.CompareExchange(ref coherentState.CacheSize, committedSize, sizeRead);
                 if (sizeRead == original)
                 {
                     return false;
@@ -798,7 +798,21 @@ public CoherentState()
             }
 #endif
 
-            internal long _cacheSize;
+            // CacheSize is Interlocked-updated on every Set/Remove when SizeLimit is set, while
+            // _stringEntries/_nonStringEntries are read on every TryGetValue; the padding keeps the
+            // write-hot atomic off the line holding those read-mostly references. It has to live in
+            // a struct -- layout attributes on a class only affect marshaling, and the runtime
+            // reorders class fields freely. 64 is the size of a cache line on many systems; larger
+            // ones may see a little more false sharing.
+            private CacheSizePadded _cacheSizePadded;
+
+            [StructLayout(LayoutKind.Explicit, Size = 128)]
+            private struct CacheSizePadded
+            {
+                [FieldOffset(64)] public long Value;
+            }
+
+            internal ref long CacheSize => ref _cacheSizePadded.Value;
 
             internal bool TryGetValue(object key, [NotNullWhen(true)] out CacheEntry? entry)
                 => key is string s ? _stringEntries.TryGetValue(s, out entry) : _nonStringEntries.TryGetValue(key, out entry);
@@ -848,7 +862,7 @@ public IEnumerable<object> GetAllKeys()
 
             internal int Count => _stringEntries.Count + _nonStringEntries.Count;
 
-            internal long Size => Volatile.Read(ref _cacheSize);
+            internal long Size => Volatile.Read(ref CacheSize);
 
             internal bool RemoveEntry(CacheEntry entry, MemoryCacheOptions options)
             {
@@ -862,7 +876,7 @@ internal bool RemoveEntry(CacheEntry entry, MemoryCacheOptions options)
                 {
                     if (options.HasSizeLimit)
                     {
-                        Interlocked.Add(ref _cacheSize, -entry.Size);
+                        Interlocked.Add(ref CacheSize, -entry.Size);
                     }
                     entry.InvokeEvictionCallbacks();
                     return true;