diff --git a/src/System.Windows.Forms/System/Windows/Forms/Accessibility/LabelEditNativeWindow.cs b/src/System.Windows.Forms/System/Windows/Forms/Accessibility/LabelEditNativeWindow.cs
index 6c675ed0348..7cce1f367d1 100644
--- a/src/System.Windows.Forms/System/Windows/Forms/Accessibility/LabelEditNativeWindow.cs
+++ b/src/System.Windows.Forms/System/Windows/Forms/Accessibility/LabelEditNativeWindow.cs
@@ -15,6 +15,7 @@ internal class LabelEditNativeWindow : NativeWindow
     private HWINEVENTHOOK _valueChangeHook;
     private HWINEVENTHOOK _textSelectionChangedHook;
     private bool _winEventHooksInstalled;
+    private bool _isReleasing;
 
     private delegate void WINEVENTPROC(
         HWINEVENTHOOK hWinEventHook,
@@ -74,8 +75,24 @@ protected override void OnHandleChange()
     {
         base.OnHandleChange();
 
+        // Prevent reentrant hook installation during ReleaseHandle.
+        // Without this guard, UnhookWinEvent can trigger OnHandleChange (via NativeWindow.Callback),
+        // causing hooks to be reinstalled on a window that is being destroyed.
+        if (_isReleasing)
+        {
+            return;
+        }
+
         if (!IsHandleCreated)
         {
+            // The native window handle was destroyed (e.g., Windows sent WM_NCDESTROY and NativeWindow
+            // cleared the handle without going through our ReleaseHandle override). Unhook the WinEvent
+            // hooks immediately so the WINEVENT_INCONTEXT hook cannot fire after _winEventProcCallback is
+            // garbage collected. Without this, the LabelEditNativeWindow is removed from the NativeWindow
+            // handle table and becomes eligible for GC while the hooks remain registered. The next
+            // CallWindowProc on any window on this thread (e.g. GridViewTextBox.DefWndProc) would then
+            // invoke the GC'd delegate and trigger a FailFast.
+            UnhookWinEventHooks();
             return;
         }
 
@@ -92,31 +109,52 @@ protected override void OnHandleChange()
 
     public override unsafe void ReleaseHandle()
     {
-        if (_winEventHooksInstalled)
+        _isReleasing = true;
+        try
         {
-            PInvoke.UnhookWinEvent(_valueChangeHook);
-            PInvoke.UnhookWinEvent(_textSelectionChangedHook);
+            UnhookWinEventHooks();
 
-            _winEventHooksInstalled = false;
-        }
+            if (IsHandleCreated)
+            {
+                // When a window that previously returned providers has been destroyed,
+                // you should notify UI Automation by calling the UiaReturnRawElementProvider
+                // as follows: UiaReturnRawElementProvider(hwnd, 0, 0, NULL). This call tells
+                // UI Automation that it can safely remove all map entries that refer to the specified window.
+                PInvoke.UiaReturnRawElementProvider(HWND, wParam: 0, lParam: 0, (IRawElementProviderSimple*)null);
+            }
 
-        if (IsHandleCreated)
+            PInvoke.UiaDisconnectProvider(AccessibilityObject);
+            AccessibilityObject = null;
+            base.ReleaseHandle();
+        }
+        finally
         {
-            // When a window that previously returned providers has been destroyed,
-            // you should notify UI Automation by calling the UiaReturnRawElementProvider
-            // as follows: UiaReturnRawElementProvider(hwnd, 0, 0, NULL). This call tells
-            // UI Automation that it can safely remove all map entries that refer to the specified window.
-            PInvoke.UiaReturnRawElementProvider(HWND, wParam: 0, lParam: 0, (IRawElementProviderSimple*)null);
+            _isReleasing = false;
         }
+    }
 
-        PInvoke.UiaDisconnectProvider(AccessibilityObject);
+    private void UnhookWinEventHooks()
+    {
+        if (_winEventHooksInstalled)
+        {
+            PInvoke.UnhookWinEvent(_valueChangeHook);
+            PInvoke.UnhookWinEvent(_textSelectionChangedHook);
+            _winEventHooksInstalled = false;
 
-        AccessibilityObject = null;
-        base.ReleaseHandle();
+            // Allow the delegate to be garbage collected now that no hook holds a reference
+            // to its underlying unmanaged function pointer.
+            _winEventProcCallback = null;
+        }
     }
 
     private void WinEventProcCallback(HWINEVENTHOOK hWinEventHook, uint eventId, HWND hwnd, int idObject, int idChild, uint idEventThread, uint dwmsEventTime)
     {
+        // Late-arriving callbacks should be ignored if we are releasing or hooks are already uninstalled.
+        if (_isReleasing || !_winEventHooksInstalled)
+        {
+            return;
+        }
+
         if (hwnd != Handle || idObject != (int)OBJECT_IDENTIFIER.OBJID_CLIENT || !IsAccessibilityObjectCreated)
         {
             return;
@@ -141,7 +179,9 @@ private void WmGetObject(ref Message m)
 
             // Accessibility object was likely requested by an assistive tech (which sent WM_GETOBJECT message).
             // We may need to install winevent hooks to produce the automation events related to the text pattern.
-            if (!_winEventHooksInstalled)
+            // However, if we are in the process of releasing the handle, skip hook installation to avoid
+            // creating new hooks on a window that is being destroyed.
+            if (!_winEventHooksInstalled && !_isReleasing)
             {
                 InstallWinEventHooks();
             }
diff --git a/src/test/unit/System.Windows.Forms/System/Windows/Forms/AccessibleObjects/TreeViewLabelEditAccessibleObjectTests.cs b/src/test/unit/System.Windows.Forms/System/Windows/Forms/AccessibleObjects/TreeViewLabelEditAccessibleObjectTests.cs
index c57a1beeefd..f524026f5a1 100644
--- a/src/test/unit/System.Windows.Forms/System/Windows/Forms/AccessibleObjects/TreeViewLabelEditAccessibleObjectTests.cs
+++ b/src/test/unit/System.Windows.Forms/System/Windows/Forms/AccessibleObjects/TreeViewLabelEditAccessibleObjectTests.cs
@@ -132,6 +132,56 @@ public void TreeViewLabelEditNativeWindow_Ctor_NullOwningTreeView_ThrowsArgument
         Assert.Throws<ArgumentNullException>(() => new TreeViewLabelEditNativeWindow(null));
     }
 
+    [WinFormsFact]
+    public void LabelEditNativeWindow_OnHandleChange_DuringRelease_DoesNotReinstallHooks()
+    {
+        using TreeView treeView = new() { Size = new Size(300, 200) };
+        treeView.CreateControl();
+
+        TreeViewLabelEditNativeWindow labelEdit = new(treeView);
+
+        labelEdit.TestAccessor.Dynamic._isReleasing = true;
+        labelEdit.TestAccessor.Dynamic.OnHandleChange();
+
+        Assert.False((bool)labelEdit.TestAccessor.Dynamic._winEventHooksInstalled);
+    }
+
+    [WinFormsFact]
+    public void TreeViewLabelEditNativeWindow_ReleaseHandle_UnhooksAndCleansUpState()
+    {
+        using TreeView treeView = new() { Size = new Size(300, 200) };
+        treeView.CreateControl();
+
+        TreeViewLabelEditNativeWindow labelEdit = new(treeView);
+        labelEdit.AssignHandle(treeView.Handle);
+
+        // Simulate hooks installed
+        labelEdit.TestAccessor.Dynamic._winEventHooksInstalled = true;
+
+        labelEdit.ReleaseHandle();
+
+        Assert.False((bool)labelEdit.TestAccessor.Dynamic._winEventHooksInstalled);
+        Assert.Null(labelEdit.TestAccessor.Dynamic._winEventProcCallback);
+    }
+
+    [WinFormsFact]
+    public void TreeViewLabelEditNativeWindow_ReleaseHandle_PreventsReentrantHookInstallation()
+    {
+        using TreeView treeView = new() { Size = new Size(300, 200) };
+        treeView.CreateControl();
+
+        TreeViewLabelEditNativeWindow labelEdit = new(treeView);
+
+        labelEdit.TestAccessor.Dynamic._isReleasing = true;
+        labelEdit.TestAccessor.Dynamic._winEventHooksInstalled = false;
+
+        // Simulates OnHandleChange being triggered mid-release
+        labelEdit.TestAccessor.Dynamic.OnHandleChange();
+
+        // Hooks must NOT be reinstalled while releasing
+        Assert.False((bool)labelEdit.TestAccessor.Dynamic._winEventHooksInstalled);
+    }
+
     [WinFormsFact]
     public void TreeViewLabelEditUiaTextProvider_Ctor_NullOwningTreeView_ThrowsArgumentNullException()
     {