diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 3bacb1d..2640b81 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -63,15 +63,15 @@ jobs: - name: Install build tools run: | sudo apt-get update -q - sudo apt-get install -y gcc autoconf automake flex bison + sudo apt-get install -y gcc autoconf automake flex bison musl-tools - name: Bootstrap (autoreconf) run: autoreconf -fi - - name: Configure + - name: Configure (dynamic — for integration tests) run: ./configure - - name: Build + - name: Build (dynamic) run: make -j$(nproc) - name: Run integration tests @@ -81,15 +81,39 @@ jobs: # when inputs are absent. run: bash tests/run_all_tests.sh --integration-only --skip-memory --skip-concurrent env: - HAZARD_BIN: ${{ github.workspace }}/hazard + HAZARD_BIN: ${{ github.workspace }}/src/hazard/hazard + HAZPRED_BIN: ${{ github.workspace }}/src/hazpred/hazpred + + - name: Upload dynamic Linux binaries as artifact + uses: actions/upload-artifact@v4 + with: + name: hazard-linux-x64-glibc-${{ github.sha }} + path: | + src/hazard/hazard + src/hazpred/hazpred + retention-days: 30 - - name: Upload hazard binary as artifact + - name: Build static binaries for deployment + # Static binaries run on any Linux x86-64 regardless of glibc version + # (RHEL 7/8, Ubuntu 18+, musl systems, etc.) + run: | + make clean + ./configure LDFLAGS=-static + make -j$(nproc) + mkdir -p dist-static + cp src/hazard/hazard dist-static/hazard + cp src/hazpred/hazpred dist-static/hazpred + file dist-static/hazard dist-static/hazpred + + - name: Upload static Linux binaries as artifact uses: actions/upload-artifact@v4 if: success() with: - name: hazard-binary-${{ github.sha }} - path: hazard - retention-days: 7 + name: hazard-linux-x64-static-${{ github.sha }} + path: | + dist-static/hazard + dist-static/hazpred + retention-days: 30 - name: Verify version badge is current # version-badge.json must be updated manually as part of any diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.lst new file mode 100644 index 0000000..6dd3af5 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.lst @@ -0,0 +1,2832 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 1533 ++1,observations available for analysis with: +/1 +@20, 338 ++1,events +/1 +@20, 1195 ++1,Right Censored Observations +/1 +@20, 1533 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup Interval (months) After Repair ++2, 0.00068 ++3, 80.19877 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1,1195 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<7 +@5,Concomitant Information: +/1 +@5,======================== +/3 +@10,Phase ++5,Variable ++6,Label ++42,Mean ++11,Min ++10,Max +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +@10,Early: ++1,AGE_COP ++6,Age (years) at current operation ++2, 54.77219 ++2, 8.23289 ++2, 84.69168 +/1 +@10, ++1,BLACK ++6,Black race ++2, 0.1154599 ++2, 0 ++2, 1 +/1 +@10, ++1,MALE ++6,Male patient ++2, 0.6190476 ++2, 0 ++2, 1 +/1 +@10, ++1,NYHA ++6,Augmented NYHA functional class ++2, 2.909389 ++2, 1 ++2, 5 +/1 +@10, ++1,AO_PINC ++6,Pure aortic incompetence ++2, 0.2367906 ++2, 0 ++2, 1 +/1 +@10, ++1,I_PATH ++6,Ischemic mitral pathology ++2, 0.02348337 ++2, 0 ++2, 1 +/1 +@10, ++1,NVE ++6,Native valve endocarditis ++2, 0.04370515 ++2, 0 ++2, 1 +/1 +@10, ++1,MITRAL ++6,Mitral valve replacement only ++2, 0.3118069 ++2, 0 ++2, 1 +/1 +@10, ++1,DOUBLE ++6,Multiple valve replacement ++2, 0.1389432 ++2, 0 ++2, 1 +/1 +@10, ++1,MECHVALV ++6,Mechanic prosthesis inserted ++2, 0.7090672 ++2, 0 ++2, 1 +/1 +@10, ++1,BIO ++6,Bioprosthesis inserted ++2, 0.3124592 ++2, 0 ++2, 2 +/1 +@20,------------------------------------------------------------------------------------------------- +/1 +@10,Constant: ++1,AGE_COP ++6,Age (years) at current operation ++2, 54.77219 ++2, 8.23289 ++2, 84.69168 +/1 +@10, ++1,BLACK ++6,Black race ++2, 0.1154599 ++2, 0 ++2, 1 +/1 +@10, ++1,MALE ++6,Male patient ++2, 0.6190476 ++2, 0 ++2, 1 +/1 +@10, ++1,NYHA ++6,Augmented NYHA functional class ++2, 2.909389 ++2, 1 ++2, 5 +/1 +@10, ++1,AO_PINC ++6,Pure aortic incompetence ++2, 0.2367906 ++2, 0 ++2, 1 +/1 +@10, ++1,I_PATH ++6,Ischemic mitral pathology ++2, 0.02348337 ++2, 0 ++2, 1 +/1 +@10, ++1,NVE ++6,Native valve endocarditis ++2, 0.04370515 ++2, 0 ++2, 1 +/1 +@10, ++1,MITRAL ++6,Mitral valve replacement only ++2, 0.3118069 ++2, 0 ++2, 1 +/1 +@10, ++1,DOUBLE ++6,Multiple valve replacement ++2, 0.1389432 ++2, 0 ++2, 1 +/1 +@10, ++1,MECHVALV ++6,Mechanic prosthesis inserted ++2, 0.7090672 ++2, 0 ++2, 1 +/1 +@10, ++1,BIO ++6,Bioprosthesis inserted ++2, 0.3124592 ++2, 0 ++2, 2 +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.6781774 ++2, 0.6781774 ++1, ++2,| ++2,E2 ++1, ++27,No +/1 +@21, ++1,(RHO ++23, 2.668966 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E3 ++1, ++27,No +/1 +@11, +; +; ++1,M +; ++6, -2.15596 ++2, -2.15596 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.09596854 ++2, 0.09596854 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -2.34373 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6, 0.00349094 ++2, 0.00349094 ++1, ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -5.65758 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M<0, Nu=0, Exponential equations 15 - 17 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Newton ++1,method using +;analytic ++1,derivatives +/1 +@21,initiated using an initial hessian matrix +/2 +@7,Conservation of events: +@31,Invoked initially +/1 +/2 +<10 +@5,Results: +/1 +@5,======== +/2 +@53,Forward Stepwise Selection +/2 +@5,* During variable selection steps, +; variances are approximate because +; shaping parameter covariances are +; ignored. +/2 +<15 +@1,*----------------------------- +;--------------------------------- +;--------------------* +/1 +@1,|Step 0. Intercepts, included +; variables, and non-fixed shaping +; parameters entered.| +/1 +@1,*----------------------------- +;--------------------------------- +;--------------------* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 8 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 0.1312119 +/1 +@9,Number of events conserved = +; 337.9609 +/2 +@9,Log likelihood = +; -1536.4 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -0.0757126 ++2, 0.0765193 ++3, -0.989 ++4, 0.3224 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -5.92177 ++2, 0.08519113 ++3, -69.512 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +@3,Early: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.04402051 ++2, 0.005419275 ++3, 8.123 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 2.324938 ++2, 0.3530116 ++3, 6.586 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2073479 ++2, 0.1525566 ++3, 1.359 ++4, 0.1741 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4262845 ++2, 0.09362366 ++3, 4.553 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, -0.309803 ++2, 0.1583265 ++3, -1.957 ++4, 0.0504 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.3832979 ++2, 0.3285011 ++3, 1.167 ++4, 0.2433 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 1.038373 ++2, 0.3575895 ++3, 2.904 ++4, 0.0037 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.6430961 ++2, 0.171049 ++3, 3.760 ++4, 0.0002 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.444521 ++2, 0.1626038 ++3, -2.734 ++4, 0.0063 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.688695 ++2, 0.2157326 ++3, -3.192 ++4, 0.0014 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.7870678 ++2, 0.201255 ++3, 3.911 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.01792216 ++2, 0.006114984 ++3, 2.931 ++4, 0.0034 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 1.111051 ++2, 0.2887856 ++3, 3.847 ++4, 0.0001 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2188755 ++2, 0.1759347 ++3, 1.244 ++4, 0.2135 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.50838 ++2, 0.1241892 ++3, 4.094 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.2706482 ++2, 0.2027125 ++3, 1.335 ++4, 0.1818 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 4.162777 ++2, 0.9568414 ++3, 4.351 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 0.3898243 ++2, 0.5160767 ++3, 0.755 ++4, 0.4500 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.1954567 ++2, 0.1918903 ++3, 1.019 ++4, 0.3084 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.226539 ++2, 0.2890455 ++3, -0.784 ++4, 0.4332 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.193512 ++2, 0.1914427 ++3, -1.011 ++4, 0.3121 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.278549 ++2, 0.1780325 ++3, 1.565 ++4, 0.1177 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 1 +;. +;AGE_COP +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; 8.123 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 6 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 4.963411 +/1 +@9,Number of events conserved = +; 337.9999 +/2 +@9,Log likelihood = +; -1500.29 +/2 +@9,-2(Difference in log likelihood) = +; 72.21108 +/1 +@9, P(diff) = +;<.0001 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -2.83655 ++2, 0.3935472 ++3, -7.208 ++2, <.0001 +/1 +<3 +@3, ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.0515126 ++2, 0.006633815 ++3, 7.765 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -5.93098 ++2, 0.08582262 ++3, -69.107 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +@3,Early: ++2,BLACK ++2,Black race ++2, 5.327335 ++2, 0.4940323 ++3, 10.783 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.1577078 ++2, 0.1522314 ++3, 1.036 ++4, 0.3002 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.7046124 ++2, 0.1129553 ++3, 6.238 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.5369783 ++2, 0.2091572 ++3, 2.567 ++4, 0.0102 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.3369325 ++2, 0.3203911 ++3, 1.052 ++4, 0.2930 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 5.88864 ++2, 0.6549464 ++3, 8.991 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.4339694 ++2, 0.1647982 ++3, 2.633 ++4, 0.0085 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, 0.02499504 ++2, 0.1949856 ++3, 0.128 ++4, 0.8980 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.5349 ++2, 0.2103428 ++3, -2.543 ++4, 0.0110 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.7224278 ++2, 0.2047955 ++3, 3.528 ++4, 0.0004 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.01325118 ++2, 0.006270601 ++3, 2.113 ++4, 0.0346 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 1.219566 ++2, 0.2934315 ++3, 4.156 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2539029 ++2, 0.1774651 ++3, 1.431 ++4, 0.1525 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4967756 ++2, 0.1259745 ++3, 3.943 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.3401801 ++2, 0.2048132 ++3, 1.661 ++4, 0.0967 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 3.813938 ++2, 0.9391418 ++3, 4.061 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 0.4445511 ++2, 0.5106485 ++3, 0.871 ++4, 0.3840 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.1803925 ++2, 0.1933148 ++3, 0.933 ++4, 0.3507 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.204642 ++2, 0.2951872 ++3, -0.693 ++4, 0.4881 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.17843 ++2, 0.1921563 ++3, -0.929 ++4, 0.3531 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.2744416 ++2, 0.1794891 ++3, 1.529 ++4, 0.1263 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 2 +;. +;BLACK +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; 10.783 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 9 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 5.125597 +/1 +@9,Number of events conserved = +; 338 +/2 +@9,Log likelihood = +; -1475.77 +/2 +@9,-2(Difference in log likelihood) = +; 49.04444 +/1 +@9, P(diff) = +;<.0001 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -3.75455 ++2, 0.4600147 ++3, -8.162 ++2, <.0001 +/1 +<3 +@3, ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.06463062 ++2, 0.007492273 ++3, 8.626 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 1.813879 ++2, 0.2197365 ++3, 8.255 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -5.94475 ++2, 0.08645662 ++3, -68.760 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +@3,Early: ++2,MALE ++2,Male patient ++2, -0.0040481 ++2, 0.15708 ++3, -0.026 ++4, 0.9794 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.5727192 ++2, 0.1210944 ++3, 4.730 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.08437932 ++2, 0.2168846 ++3, 0.389 ++4, 0.6972 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.6363653 ++2, 0.355389 ++3, 1.791 ++4, 0.0734 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 13.11926 ++2, 0.9346157 ++3, 14.037 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.4988594 ++2, 0.165738 ++3, 3.010 ++4, 0.0026 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, 0.370909 ++2, 0.2141392 ++3, 1.732 ++4, 0.0833 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.369872 ++2, 0.1988758 ++3, -1.860 ++4, 0.0629 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.5342426 ++2, 0.190906 ++3, 2.798 ++4, 0.0051 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.01312834 ++2, 0.006313618 ++3, 2.079 ++4, 0.0376 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 0.8853835 ++2, 0.2917476 ++3, 3.035 ++4, 0.0024 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2379575 ++2, 0.1787197 ++3, 1.331 ++4, 0.1830 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4750741 ++2, 0.1274821 ++3, 3.727 ++4, 0.0002 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.3209311 ++2, 0.2064356 ++3, 1.555 ++4, 0.1200 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 4.194628 ++2, 0.967494 ++3, 4.336 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 0.4660334 ++2, 0.5223952 ++3, 0.892 ++4, 0.3723 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.1680054 ++2, 0.194145 ++3, 0.865 ++4, 0.3868 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.260023 ++2, 0.2970324 ++3, -0.875 ++4, 0.3814 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.142676 ++2, 0.1934644 ++3, -0.737 ++4, 0.4608 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.231665 ++2, 0.1806758 ++3, 1.282 ++4, 0.1998 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 3 +;. +;NVE +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; 14.037 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 8 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 5.177282 +/1 +@9,Number of events conserved = +; 337.9999 +/2 +@9,Log likelihood = +; -1452.8 +/2 +@9,-2(Difference in log likelihood) = +; 45.94518 +/1 +@9, P(diff) = +;<.0001 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -4.78053 ++2, 0.4659003 ++3, -10.261 ++2, <.0001 +/1 +<3 +@3, ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.07959524 ++2, 0.00735832 ++3, 10.817 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 2.090167 ++2, 0.2171669 ++3, 9.625 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 2.303623 ++2, 0.2663474 ++3, 8.649 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -5.94679 ++2, 0.08641113 ++3, -68.820 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +@3,Early: ++2,MALE ++2,Male patient ++2, -0.0829588 ++2, 0.1591744 ++3, -0.521 ++4, 0.6022 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.2357466 ++2, 0.1175248 ++3, 2.006 ++4, 0.0449 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, -0.223481 ++2, 0.229204 ++3, -0.975 ++4, 0.3295 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.9807775 ++2, 0.3921781 ++3, 2.501 ++4, 0.0124 ++3, 1 +/1 +<3 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.5312916 ++2, 0.1690577 ++3, 3.143 ++4, 0.0017 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, 0.07608058 ++2, 0.2267502 ++3, 0.336 ++4, 0.7372 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.254869 ++2, 0.1999482 ++3, -1.275 ++4, 0.2024 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.3961683 ++2, 0.1881148 ++3, 2.106 ++4, 0.0352 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.01230054 ++2, 0.00632795 ++3, 1.944 ++4, 0.0519 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 0.8453945 ++2, 0.2909167 ++3, 2.906 ++4, 0.0037 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2296192 ++2, 0.1787688 ++3, 1.284 ++4, 0.1990 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4459591 ++2, 0.1266603 ++3, 3.521 ++4, 0.0004 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.281837 ++2, 0.2055565 ++3, 1.371 ++4, 0.1703 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 4.570408 ++2, 0.9916695 ++3, 4.609 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, -0.117768 ++2, 0.4682753 ++3, -0.251 ++4, 0.8014 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.186575 ++2, 0.1941045 ++3, 0.961 ++4, 0.3364 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.293779 ++2, 0.2962942 ++3, -0.992 ++4, 0.3214 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.0975918 ++2, 0.1929386 ++3, -0.506 ++4, 0.6130 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.1776921 ++2, 0.1796988 ++3, 0.989 ++4, 0.3227 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 4 +;. +;I_PATH +; added to +;CONSTANT PHASE ++10,| +/1 +@1,| ++19,with Z = +; 4.609 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 9 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 5.138546 +/1 +@9,Number of events conserved = +; 338 +/2 +@9,Log likelihood = +; -1448.49 +/2 +@9,-2(Difference in log likelihood) = +; 8.610968 +/1 +@9, P(diff) = +; 0.0033 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -4.80942 ++2, 0.4682646 ++3, -10.271 ++2, <.0001 +/1 +<3 +@3, ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.07989682 ++2, 0.007390602 ++3, 10.811 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 2.10575 ++2, 0.2173572 ++3, 9.688 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 2.318676 ++2, 0.2662611 ++3, 8.708 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -5.98122 ++2, 0.08833193 ++3, -67.713 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 1.441798 ++2, 0.3877227 ++3, 3.719 ++4, 0.0002 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +@3,Early: ++2,MALE ++2,Male patient ++2, -0.0923003 ++2, 0.1599737 ++3, -0.577 ++4, 0.5640 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.2279404 ++2, 0.1179159 ++3, 1.933 ++4, 0.0532 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, -0.207719 ++2, 0.2302611 ++3, -0.902 ++4, 0.3670 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.8139077 ++2, 0.410549 ++3, 1.982 ++4, 0.0474 ++3, 1 +/1 +<3 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.5065956 ++2, 0.1703848 ++3, 2.973 ++4, 0.0029 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, 0.09583499 ++2, 0.2280242 ++3, 0.420 ++4, 0.6743 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.239572 ++2, 0.2014466 ++3, -1.189 ++4, 0.2343 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.384385 ++2, 0.189356 ++3, 2.030 ++4, 0.0424 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.0112647 ++2, 0.006421686 ++3, 1.754 ++4, 0.0794 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 0.8302551 ++2, 0.2901859 ++3, 2.861 ++4, 0.0042 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.2108364 ++2, 0.178874 ++3, 1.179 ++4, 0.2385 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4121107 ++2, 0.127758 ++3, 3.226 ++4, 0.0013 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.340802 ++2, 0.2097653 ++3, 1.625 ++4, 0.1042 ++3, 1 +/1 +<3 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, -0.0859346 ++2, 0.4768635 ++3, -0.180 ++4, 0.8570 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.06120974 ++2, 0.1998514 ++3, 0.306 ++4, 0.7594 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.265488 ++2, 0.3023072 ++3, -0.878 ++4, 0.3798 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.131131 ++2, 0.1939854 ++3, -0.676 ++4, 0.4990 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.2105734 ++2, 0.1810596 ++3, 1.163 ++4, 0.2448 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 5 +;. +;NYHA +; added to +;CONSTANT PHASE ++10,| +/1 +@1,| ++19,with Z = +; 3.226 +; and P = +; 0.0013 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 5 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 5.148369 +/1 +@9,Number of events conserved = +; 337.9999 +/2 +@9,Log likelihood = +; -1443.28 +/2 +@9,-2(Difference in log likelihood) = +; 10.43181 +/1 +@9, P(diff) = +; 0.0012 +/2 +<2 +$Note: Program being stopped by MAXSTEPS. +/1 +@5,*** Stopping after maximum steps specified. +/2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -4.78068 ++2, 0.4694778 ++3, -10.183 ++2, <.0001 +/1 +<3 +@3, ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.07938922 ++2, 0.007416339 ++3, 10.705 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 2.088636 ++2, 0.2189013 ++3, 9.541 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, 2.303782 ++2, 0.2684355 ++3, 8.582 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -7.19 ++2, 0.3959209 ++3, -18.160 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.4125465 ++2, 0.1271765 ++3, 3.244 ++4, 0.0012 ++3, 1 +/1 +<3 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 1.22588 ++2, 0.3922085 ++3, 3.126 ++4, 0.0018 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +@3,Early: ++2,MALE ++2,Male patient ++2, -0.0849072 ++2, 0.1605445 ++3, -0.529 ++4, 0.5969 ++3, 1 +/1 +<3 +@3, ++2,NYHA ++2,Augmented NYHA functional class ++2, 0.1918075 ++2, 0.1187405 ++3, 1.615 ++4, 0.1062 ++3, 1 +/1 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, -0.184285 ++2, 0.2314697 ++3, -0.796 ++4, 0.4259 ++3, 1 +/1 +<3 +@3, ++2,I_PATH ++2,Ischemic mitral pathology ++2, 0.8143942 ++2, 0.4078483 ++3, 1.997 ++4, 0.0458 ++3, 1 +/1 +<3 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.5029062 ++2, 0.1710944 ++3, 2.939 ++4, 0.0033 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, 0.08749699 ++2, 0.2279746 ++3, 0.384 ++4, 0.7011 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.232867 ++2, 0.2021404 ++3, -1.152 ++4, 0.2493 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.3805618 ++2, 0.1900243 ++3, 2.003 ++4, 0.0452 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE_COP ++2,Age (years) at current operation ++2, 0.008353791 ++2, 0.006590153 ++3, 1.268 ++4, 0.2049 ++3, 1 +/1 +<3 +@3, ++2,BLACK ++2,Black race ++2, 0.7921322 ++2, 0.2855428 ++3, 2.774 ++4, 0.0055 ++3, 1 +/1 +<3 +@3, ++2,MALE ++2,Male patient ++2, 0.285089 ++2, 0.1776623 ++3, 1.605 ++4, 0.1086 ++3, 1 +/1 +<3 +<3 +@3, ++2,AO_PINC ++2,Pure aortic incompetence ++2, 0.3346397 ++2, 0.2099554 ++3, 1.594 ++4, 0.1110 ++3, 1 +/1 +<3 +<3 +@3, ++2,NVE ++2,Native valve endocarditis ++2, -0.279299 ++2, 0.4327977 ++3, -0.645 ++4, 0.5187 ++3, 1 +/1 +<3 +@3, ++2,MITRAL ++2,Mitral valve replacement only ++2, 0.01262703 ++2, 0.1967014 ++3, 0.064 ++4, 0.9488 ++3, 1 +/1 +<3 +@3, ++2,DOUBLE ++2,Multiple valve replacement ++2, -0.327984 ++2, 0.2897198 ++3, -1.132 ++4, 0.2576 ++3, 1 +/1 +<3 +@3, ++2,MECHVALV ++2,Mechanic prosthesis inserted ++2, -0.161906 ++2, 0.1941706 ++3, -0.834 ++4, 0.4044 ++3, 1 +/1 +<3 +@3, ++2,BIO ++2,Bioprosthesis inserted ++2, 0.2234234 ++2, 0.1790207 ++3, 1.248 ++4, 0.2120 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@5,Final Results: +/1 +@5,============== +/3 +@51,Parameter Estimate Summary +/2 +@5,Phase ++6,Parameter ++3,Label ++39,Estimate ++7,Std error ++13,Z ++10,Prob>|Z| +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Early: ++2,E0 ++4, ++3, -4.78068 ++3, 0.4694778 ++4, -10.183 ++4, <.0001 +/1 +<3 +@5, ++2,AGE_COP ++4,Age (years) at current operation ++3, 0.07938922 ++3, 0.007416339 ++4, 10.705 ++4, <.0001 +/1 +<3 +@5, ++2,BLACK ++4,Black race ++3, 2.088636 ++3, 0.2189013 ++4, 9.541 ++4, <.0001 +/1 +<3 +@5, ++2,NVE ++4,Native valve endocarditis ++3, 2.303782 ++3, 0.2684355 ++4, 8.582 ++4, <.0001 +/1 +@16,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Constant: ++2,C0 ++4, ++3, -7.19 ++3, 0.3959209 ++4, -18.160 ++4, <.0001 +/1 +<3 +@5, ++2,NYHA ++4,Augmented NYHA functional class ++3, 0.4125465 ++3, 0.1271765 ++4, 3.244 ++6, 0.0012 +/1 +<3 +@5, ++2,I_PATH ++4,Ischemic mitral pathology ++3, 1.22588 ++3, 0.3922085 ++4, 3.126 ++6, 0.0018 +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<20 +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,Yes ++7, 0.6781774 +/1 +@55, (RHO ++19, 2.668966 +;) +/1 +@43, +; +@55,NU +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,M +; ++6,Yes ++7, -2.15596 +/1 +@43, ++3,MUE ++6, ++7, 0.008390311 +/1 +@55,------------------------------------ +/1 +@43,Constant: ++3,MUC ++6, ++7,0.0007540877 +/1 +@43,------------------------------------------------ +/1 +$Note: Procedure HAZARD completed successfully. diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.meta new file mode 100644 index 0000000..09bbb2b --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.deadp.VALVES.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593516.2563816250.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:16Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.lst new file mode 100644 index 0000000..a2d5584 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.lst @@ -0,0 +1,3321 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 310 ++1,observations available for analysis with: +/1 +@20, 70 ++1,events +/1 +@20, 240 ++1,Right Censored Observations +/1 +@20, 310 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup interval (months) after repair ++2, 0.001368954 ++3, 170.5826 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1, 240 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<7 +@5,Concomitant Information: +/1 +@5,======================== +/3 +@10,Phase ++5,Variable ++6,Label ++42,Mean ++11,Min ++10,Max +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +@10,Early: ++1,AGE ++6,Age (months) at repair ++2, 120.2347 ++2, 0.9199368 ++2, 790.9813 +/1 +@10, ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@10, ++1,COM_IV ++6,Interventricular communication ++2, 0.5032258 ++2, 0 ++2, 1 +/1 +@10, ++1,ORIFICE ++6,Accessory left AV valve orifice ++2, 0.04516129 ++2, 0 ++2, 1 +/1 +@10, ++1,MAL ++6,Important associated cardiac anomaly ++2, 0.2354839 ++2, 0 ++2, 1 +/1 +@10, ++1,INC_SURG ++6,Surgical grade of AV valve incompetence ++2, 2.393443 ++2, 0 ++2, 5 +/1 +@10, ++1,OPMOS ++6,Date of operation (months since 1/67) ++2, 116.7377 ++2, 2.661246 ++2, 179.9462 +/1 +@10, ++1,OP_AGE ++6, ++2, 12632.69 ++2, 64.68025 ++2, 125813.4 +/1 +@20,------------------------------------------------------------------------------------------------- +/1 +@10,Constant: ++1,AGE ++6,Age (months) at repair ++2, 120.2347 ++2, 0.9199368 ++2, 790.9813 +/1 +@10, ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@10, ++1,COM_IV ++6,Interventricular communication ++2, 0.5032258 ++2, 0 ++2, 1 +/1 +@10, ++1,ORIFICE ++6,Accessory left AV valve orifice ++2, 0.04516129 ++2, 0 ++2, 1 +/1 +@10, ++1,MAL ++6,Important associated cardiac anomaly ++2, 0.2354839 ++2, 0 ++2, 1 +/1 +@10, ++1,INC_SURG ++6,Surgical grade of AV valve incompetence ++2, 2.393443 ++2, 0 ++2, 5 +/1 +@10, ++1,OPMOS ++6,Date of operation (months since 1/67) ++2, 116.7377 ++2, 2.661246 ++2, 179.9462 +/1 +@10, ++1,OP_AGE ++6, ++2, 12632.69 ++2, 64.68025 ++2, 125813.4 +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.1511909 ++2, 0.1511909 ++1, ++2,| ++2,E2 ++1, ++27,No +/1 +@21, ++1,(RHO ++23, 0.1511909 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1.438631 ++2, 1.438631 ++1, ++2,| ++2,E3 ++1, ++27,No +/1 +@11, +; +; ++1,M +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.2361697 ++2, 0.2361697 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -1.4432 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6,0.0005437256 ++2,0.0005437256 ++1,* ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -7.51707 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Newton ++1,method using +;analytic ++1,derivatives +/1 +@21,initiated using an initial hessian matrix +/2 +@7,Conservation of events: +@31,Invoked initially +/1 +/2 +<10 +@5,Results: +/1 +@5,======== +/2 +@53,Forward Stepwise Selection +/2 +@5,* During variable selection steps, +; variances are approximate because +; shaping parameter covariances are +; ignored. +/2 +<15 +@1,*----------------------------- +;--------------------------------- +;--------------------* +/1 +@1,|Step 0. Intercepts, included +; variables, and non-fixed shaping +; parameters entered.| +/1 +@1,*----------------------------- +;--------------------------------- +;--------------------* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 9 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 8.984351 +/1 +@9,Number of events conserved = +; 69.99994 +/2 +@9,Log likelihood = +; -196.427 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -0.688538 ++2, 0.3344273 ++3, -2.059 ++4, 0.0395 +/1 +<3 +<3 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.04429 ++2, 0.3939178 ++3, -2.651 ++4, 0.0080 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.5391314 ++2, 0.2893691 ++3, 1.863 ++4, 0.0624 ++3, 0 +/1 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -8.55857 ++2, 1.718561 ++3, -4.980 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.817384 ++2, 0.9785974 ++3, 2.879 ++4, 0.0040 ++3, 1 +/1 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -0.0735822 ++2, 1.329058 ++3, -0.055 ++4, 0.9558 ++3, 1 +/1 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.6122856 ++2, 0.4911709 ++3, 1.247 ++4, 0.2126 ++3, 0 +/1 +<3 +<3 +@3, ++2,OP_AGE ++2, ++2,-9.64308E-05 ++2,8.530711E-05 ++3, -1.130 ++4, 0.2583 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +@3,Early: ++2,AGE ++2,Age (months) at repair ++2, -0.00339482 ++2,0.0009930044 ++3, -3.419 ++4, 0.0006 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.250703 ++2, 0.221204 ++3, 5.654 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 0.4261263 ++2, 0.5446248 ++3, 0.782 ++4, 0.4340 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.4944597 ++2, 0.1279628 ++3, 3.864 ++4, 0.0001 ++3, 1 +/1 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, 0.001118683 ++2, 0.003008258 ++3, 0.372 ++4, 0.7100 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.09865E-05 ++2,1.149594E-05 ++3, -1.826 ++4, 0.0679 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.06416355 ++2, 0.01355233 ++3, 4.735 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.885154 ++2, 0.752029 ++3, 2.507 ++4, 0.0122 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.94622 ++2, 1.191455 ++3, -1.633 ++4, 0.1024 ++3, 0 +/1 +<3 +<3 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.04024 ++2, 0.02104311 ++3, -1.912 ++4, 0.0558 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 1 +;. +;MAL +; deleted from +;CONSTANT PHASE ++6,| +/1 +@1,| ++19,with Z = +; -0.055 +; and P = +; 0.9558 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 3 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 8.936501 +/1 +@9,Number of events conserved = +; 70 +/2 +@9,Log likelihood = +; -196.428 +/2 +@9,-2(Difference in log likelihood) = +; 0.003173363 +/1 +@9, P(diff) = +; 0.9551 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -0.68815 ++2, 0.3343084 ++3, -2.058 ++4, 0.0395 +/1 +<3 +<3 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.04371 ++2, 0.3935475 ++3, -2.652 ++4, 0.0080 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.5370162 ++2, 0.2867289 ++3, 1.873 ++4, 0.0611 ++3, 0 +/1 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -8.54736 ++2, 1.666411 ++3, -5.129 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.81356 ++2, 0.9721095 ++3, 2.894 ++4, 0.0038 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.6052794 ++2, 0.4655356 ++3, 1.300 ++4, 0.1935 ++3, 0 +/1 +<3 +<3 +@3, ++2,OP_AGE ++2, ++2,-9.60926E-05 ++2,8.469841E-05 ++3, -1.135 ++4, 0.2566 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +@3,Early: ++2,AGE ++2,Age (months) at repair ++2, -0.00339105 ++2,0.0009922966 ++3, -3.417 ++4, 0.0006 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.251681 ++2, 0.2212792 ++3, 5.657 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 0.4265591 ++2, 0.5444054 ++3, 0.784 ++4, 0.4333 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.4878538 ++2, 0.1269958 ++3, 3.841 ++4, 0.0001 ++3, 1 +/1 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, 0.001120608 ++2, 0.002989085 ++3, 0.375 ++4, 0.7077 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.09661E-05 ++2,1.148527E-05 ++3, -1.825 ++4, 0.0679 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.06469277 ++2, 0.01360368 ++3, 4.756 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.922716 ++2, 0.7601362 ++3, 2.529 ++4, 0.0114 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.48213 ++2, 1.029568 ++3, -1.440 ++4, 0.1500 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -0.0701812 ++2, 1.265405 ++3, -0.055 ++4, 0.9558 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0219556 ++2, 0.01533633 ++3, -1.432 ++4, 0.1523 ++3, 1 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 2 +;. +;OP_AGE +; deleted from +;CONSTANT PHASE ++6,| +/1 +@1,| ++19,with Z = +; -1.135 +; and P = +; 0.2566 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 7 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 3.429315 +/1 +@9,Number of events conserved = +; 69.99999 +/2 +@9,Log likelihood = +; -197.393 +/2 +@9,-2(Difference in log likelihood) = +; 1.930102 +/1 +@9, P(diff) = +; 0.1647 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -0.635114 ++2, 0.3321243 ++3, -1.912 ++4, 0.0558 +/1 +<3 +<3 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.08229 ++2, 0.3937124 ++3, -2.749 ++4, 0.0060 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.5414765 ++2, 0.2881006 ++3, 1.879 ++4, 0.0602 ++3, 0 +/1 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -10.5019 ++2, 4.176934 ++3, -2.514 ++4, 0.0119 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.830191 ++2, 1.062872 ++3, 2.663 ++4, 0.0077 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.9488628 ++2, 1.11167 ++3, 0.854 ++4, 0.3934 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +@3,Early: ++2,AGE ++2,Age (months) at repair ++2, -0.00352695 ++2,0.0009743885 ++3, -3.620 ++4, 0.0003 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.187036 ++2, 0.2151408 ++3, 5.517 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 0.3957975 ++2, 0.5181337 ++3, 0.764 ++4, 0.4449 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.5280391 ++2, 0.1335456 ++3, 3.954 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2,0.0009106963 ++2, 0.003312445 ++3, 0.275 ++4, 0.7834 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.47176E-05 ++2,1.165031E-05 ++3, -2.122 ++4, 0.0339 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.00578181 ++2, 0.006462588 ++3, 0.895 ++4, 0.3710 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 7.5954 ++2, 1.435257 ++3, 5.292 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.45619 ++2, 1.207448 ++3, -1.206 ++4, 0.2278 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0 ++2, . ++3, . ++4, . +; *** +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, 0 ++2, . ++3, . ++4, . +; *** +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-0.000155447 ++2,8.035436E-05 ++3, -1.935 ++4, 0.0530 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +@5,*** Tolerance of the Q is zero or +; negative. +/2 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 3 +;. +;STATUS +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; 5.517 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 7 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 3.080764 +/1 +@9,Number of events conserved = +; 69.99981 +/2 +@9,Log likelihood = +; -183.643 +/2 +@9,-2(Difference in log likelihood) = +; 27.50121 +/1 +@9, P(diff) = +;<.0001 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -2.83188 ++2, 0.5660579 ++3, -5.003 ++2, <.0001 +/1 +<3 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.03149 ++2, 0.1921807 ++3, 5.367 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -1.82468 ++2, 0.3929549 ++3, -4.643 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.7516508 ++2, 0.2893418 ++3, 2.598 ++4, 0.0094 ++3, 0 +/1 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -8.53081 ++2, 1.171806 ++3, -7.280 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.78947 ++2, 0.9664749 ++3, 2.886 ++4, 0.0039 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.3305745 ++2, 0.4109707 ++3, 0.804 ++4, 0.4212 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +@3,Early: ++2,AGE ++2,Age (months) at repair ++2, -0.00220937 ++2,0.0008786434 ++3, -2.515 ++4, 0.0119 ++3, 1 +/1 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.0935699 ++2, 0.4707954 ++3, -0.199 ++4, 0.8425 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.29774 ++2, 0.1242499 ++3, 2.396 ++4, 0.0166 ++3, 1 +/1 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.00589751 ++2, 0.003384865 ++3, -1.742 ++4, 0.0815 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-1.28613E-05 ++2,9.277673E-06 ++3, -1.386 ++4, 0.1657 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2,-0.000791986 ++2, 0.003109994 ++3, -0.255 ++4, 0.7990 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.3560331 ++2, 0.6262015 ++3, 0.569 ++4, 0.5697 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -0.0998819 ++2, 1.137374 ++3, -0.088 ++4, 0.9300 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.02907124 ++2, 1.418232 ++3, 0.020 ++4, 0.9836 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0311545 ++2, 0.01600291 ++3, -1.947 ++4, 0.0516 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-3.39327E-05 ++2,2.977304E-05 ++3, -1.140 ++4, 0.2544 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 4 +;. +;AGE +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; -2.515 +; and P = +; 0.0119 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 6 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 6.200739 +/1 +@9,Number of events conserved = +; 69.99996 +/2 +@9,Log likelihood = +; -179.927 +/2 +@9,-2(Difference in log likelihood) = +; 7.431087 +/1 +@9, P(diff) = +; 0.0064 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -1.87023 ++2, 0.6571917 ++3, -2.846 ++4, 0.0044 +/1 +<3 +@3, ++2,AGE ++2,Age (months) at repair ++2, -0.0029715 ++2, 0.001293454 ++3, -2.297 ++4, 0.0216 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.8844828 ++2, 0.1970958 ++3, 4.488 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -2.19759 ++2, 0.3832599 ++3, -5.734 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 0.7180749 ++2, 0.2906627 ++3, 2.470 ++4, 0.0135 ++3, 0 +/1 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -8.73016 ++2, 1.388725 ++3, -6.286 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.73229 ++2, 1.015118 ++3, 2.692 ++4, 0.0071 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.3827478 ++2, 0.4590123 ++3, 0.834 ++4, 0.4044 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +<3 +@3,Early: ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.502296 ++2, 0.4466522 ++3, -1.125 ++4, 0.2608 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.3022513 ++2, 0.1335741 ++3, 2.263 ++4, 0.0236 ++3, 1 +/1 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0126714 ++2, 0.00394052 ++3, -3.216 ++4, 0.0013 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,4.340144E-05 ++2,2.426212E-05 ++3, 1.789 ++4, 0.0736 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2,0.0007019531 ++2, 0.003715096 ++3, 0.189 ++4, 0.8501 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.5135657 ++2, 0.6496266 ++3, 0.791 ++4, 0.4292 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -0.343207 ++2, 1.203759 ++3, -0.285 ++4, 0.7756 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -0.209856 ++2, 1.661328 ++3, -0.126 ++4, 0.8995 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0571324 ++2, 0.02031661 ++3, -2.812 ++4, 0.0049 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-4.78691E-05 ++2,4.074824E-05 ++3, -1.175 ++4, 0.2401 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 5 +;. +;OPMOS +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; -3.216 +; and P = +; 0.0013 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 6 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 6.625603 +/1 +@9,Number of events conserved = +; 70 +/2 +@9,Log likelihood = +; -175.122 +/2 +@9,-2(Difference in log likelihood) = +; 9.610877 +/1 +@9, P(diff) = +; 0.0019 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, -0.698979 ++2, 0.7122755 ++3, -0.981 ++4, 0.3264 +/1 +<3 +@3, ++2,AGE ++2,Age (months) at repair ++2, -0.0042353 ++2, 0.001352444 ++3, -3.132 ++4, 0.0017 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.1247 ++2, 0.2086402 ++3, 5.391 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -2.82735 ++2, 0.4351031 ++3, -6.498 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 1.116397 ++2, 0.3131638 ++3, 3.565 ++4, 0.0004 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0112233 ++2, 0.00347271 ++3, -3.232 ++4, 0.0012 ++3, 1 +/1 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -9.497 ++2, 1.800064 ++3, -5.276 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.903073 ++2, 1.059334 ++3, 2.740 ++4, 0.0061 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.5866163 ++2, 0.5472648 ++3, 1.072 ++4, 0.2838 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +<3 +@3,Early: ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.671553 ++2, 0.4099535 ++3, -1.638 ++4, 0.1014 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.277487 ++2, 0.1383596 ++3, 2.006 ++4, 0.0449 ++3, 1 +/1 +<3 +<3 +@3, ++2,OP_AGE ++2, ++2,0.0001443322 ++2,3.452582E-05 ++3, 4.180 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.005848813 ++2, 0.00828753 ++3, 0.706 ++4, 0.4804 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.3872254 ++2, 0.8413025 ++3, 0.460 ++4, 0.6453 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, 0.5538118 ++2, 1.542982 ++3, 0.359 ++4, 0.7197 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -1.22798 ++2, 1.548891 ++3, -0.793 ++4, 0.4279 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, 0 ++2, . ++3, . ++4, . +; *** +/1 +<3 +@3, ++2,OP_AGE ++2, ++2, 0 ++2, . ++3, . ++4, . +; *** +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +@5,*** Tolerance of the Q is zero or +; negative. +/2 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 6 +;. +;OP_AGE +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; 4.180 +; and P = +;<.0001 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 10 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 10.46053 +/1 +@9,Number of events conserved = +; 70 +/2 +@9,Log likelihood = +; -166.566 +/2 +@9,-2(Difference in log likelihood) = +; 17.11037 +/1 +@9, P(diff) = +;<.0001 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, 0.9921096 ++2, 0.7504216 ++3, 1.322 ++4, 0.1861 +/1 +<3 +@3, ++2,AGE ++2,Age (months) at repair ++2, -0.0298945 ++2, 0.009322348 ++3, -3.207 ++4, 0.0013 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.9797339 ++2, 0.1917858 ++3, 5.108 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -3.14371 ++2, 0.400356 ++3, -7.852 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 1.464631 ++2, 0.3094099 ++3, 4.734 ++2, <.0001 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0201961 ++2, 0.003839358 ++3, -5.260 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,0.0001958949 ++2,5.953814E-05 ++3, 3.290 ++4, 0.0010 ++3, 1 +/1 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -9.3843 ++2, 1.404796 ++3, -6.680 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.672621 ++2, 0.9744229 ++3, 2.743 ++4, 0.0061 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.6205175 ++2, 0.4245925 ++3, 1.461 ++4, 0.1439 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +<3 +@3,Early: ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.624776 ++2, 0.3891882 ++3, -1.605 ++4, 0.1084 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.1115485 ++2, 0.1416269 ++3, 0.788 ++4, 0.4309 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.001454164 ++2, 0.003097679 ++3, 0.469 ++4, 0.6388 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.3958423 ++2, 0.5984375 ++3, 0.661 ++4, 0.5083 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, 0.139912 ++2, 1.207216 ++3, 0.116 ++4, 0.9077 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -1.159 ++2, 1.272988 ++3, -0.910 ++4, 0.3626 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0194966 ++2, 0.01550669 ++3, -1.257 ++4, 0.2086 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.44738E-05 ++2,3.012945E-05 ++3, -0.812 ++4, 0.4166 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 7 +;. +;ORIFICE +; added to +;EARLY PHASE ++10,| +/1 +@1,| ++19,with Z = +; -1.605 +; and P = +; 0.1084 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 6 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 10.40166 +/1 +@9,Number of events conserved = +; 70 +/2 +@9,Log likelihood = +; -165.106 +/2 +@9,-2(Difference in log likelihood) = +; 2.921336 +/1 +@9, P(diff) = +; 0.0874 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, 1.171758 ++2, 0.7292872 ++3, 1.607 ++4, 0.1081 +/1 +<3 +@3, ++2,AGE ++2,Age (months) at repair ++2, -0.0300569 ++2, 0.009293339 ++3, -3.234 ++4, 0.0012 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 1.041885 ++2, 0.1921618 ++3, 5.422 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -3.40512 ++2, 0.4207236 ++3, -8.093 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.765778 ++2, 0.4889901 ++3, -1.566 ++4, 0.1173 ++3, 1 +/1 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 1.459365 ++2, 0.3106681 ++3, 4.698 ++2, <.0001 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0204078 ++2, 0.003746456 ++3, -5.447 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,0.0001937327 ++2,5.931295E-05 ++3, 3.266 ++4, 0.0011 ++3, 1 +/1 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -9.35443 ++2, 1.369714 ++3, -6.829 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.842857 ++2, 0.9325452 ++3, 3.048 ++4, 0.0023 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.6041605 ++2, 0.414151 ++3, 1.459 ++4, 0.1446 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,Early: ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.04139139 ++2, 0.157439 ++3, 0.263 ++4, 0.7926 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.001344315 ++2, 0.003104969 ++3, 0.433 ++4, 0.6650 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.3212446 ++2, 0.5860061 ++3, 0.548 ++4, 0.5836 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, 0.3243796 ++2, 1.262909 ++3, 0.257 ++4, 0.7973 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -1.15975 ++2, 1.260065 ++3, -0.920 ++4, 0.3574 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0148441 ++2, 0.01430093 ++3, -1.038 ++4, 0.2993 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.48072E-05 ++2,3.029298E-05 ++3, -0.819 ++4, 0.4128 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<15 +/2 +@1,* +;---------------------------------------------------------- +;* +/1 +@1,|Step +; 8 +;. +;ORIFICE +; deleted from +;EARLY PHASE ++6,| +/1 +@1,| ++19,with Z = +; -1.566 +; and P = +; 0.1173 +;| +/1 +@1,* +;---------------------------------------------------------- +;* +/2 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 4 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 10.4599 +/1 +@9,Number of events conserved = +; 69.99999 +/2 +@9,Log likelihood = +; -166.566 +/2 +@9,-2(Difference in log likelihood) = +; 2.921336 +/1 +@9, P(diff) = +; 0.0874 +/2 +<2 +<12 +@51,Summary of Variables in the Model +/1 +@51,--------------------------------- +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Early: ++2,E0 ++2, ++2, 0.9921098 ++2, 0.7504215 ++3, 1.322 ++4, 0.1861 +/1 +<3 +@3, ++2,AGE ++2,Age (months) at repair ++2, -0.0298945 ++2, 0.009322347 ++3, -3.207 ++4, 0.0013 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.9797339 ++2, 0.1917858 ++3, 5.108 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, -3.14372 ++2, 0.400356 ++3, -7.852 ++2, <.0001 ++3, 1 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, 1.464631 ++2, 0.3094099 ++3, 4.734 ++2, <.0001 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0201961 ++2, 0.003839358 ++3, -5.260 ++2, <.0001 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,0.0001958949 ++2,5.953814E-05 ++3, 3.290 ++4, 0.0010 ++3, 1 +/1 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@3,Constant: ++2,C0 ++2, ++2, -9.3843 ++2, 1.404795 ++3, -6.680 ++2, <.0001 +/1 +<3 +<3 +<3 +<3 +@3, ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, 2.672621 ++2, 0.9744226 ++3, 2.743 ++4, 0.0061 ++3, 1 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.620517 ++2, 0.4245923 ++3, 1.461 ++4, 0.1439 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/2 +<12 +@36,Summary of Variables not in the Model +; (Based on Q Statistics) +/2 +@122,Moves +/1 +@3,Phase ++6,Variable ++2,Label ++38,Estimate ++6,Std error ++12,Z ++8,Prob>|Z| ++3,Remaining +/1 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +<3 +<3 +<3 +<3 +@3,Early: ++2,ORIFICE ++2,Accessory left AV valve orifice ++2, -0.624777 ++2, 0.3891881 ++3, -1.605 ++4, 0.1084 ++3, 0 +/1 +<3 +<3 +@3, ++2,INC_SURG ++2,Surgical grade of AV valve incompetence ++2, 0.1115482 ++2, 0.1416268 ++3, 0.788 ++4, 0.4309 ++3, 1 +/1 +<3 +<3 +<3 +<3 +@14,--------------------------------------------------------------------------------------------------------------------- +/1 +@3,Constant: ++2,AGE ++2,Age (months) at repair ++2, 0.00145416 ++2, 0.003097678 ++3, 0.469 ++4, 0.6388 ++3, 1 +/1 +<3 +@3, ++2,STATUS ++2,Clinical status (NYHA I-V) ++2, 0.3958404 ++2, 0.5984374 ++3, 0.661 ++4, 0.5083 ++3, 1 +/1 +<3 +@3, ++2,COM_IV ++2,Interventricular communication ++2, 0.1399119 ++2, 1.207216 ++3, 0.116 ++4, 0.9077 ++3, 0 +/1 +<3 +<3 +@3, ++2,MAL ++2,Important associated cardiac anomaly ++2, -1.159 ++2, 1.272988 ++3, -0.910 ++4, 0.3626 ++3, 0 +/1 +<3 +<3 +@3, ++2,OPMOS ++2,Date of operation (months since 1/67) ++2, -0.0194966 ++2, 0.01550669 ++3, -1.257 ++4, 0.2086 ++3, 1 +/1 +<3 +@3, ++2,OP_AGE ++2, ++2,-2.44738E-05 ++2,3.012945E-05 ++3, -0.812 ++4, 0.4166 ++3, 0 +/1 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +<3 +@3,-------------------------------------------------------------------------------------------------------------------------------- +/1 +/1 +@5,No other variables met the +; 0.2 +; significance level for entry +; into the model +;. +/2 +<15 +/2 +@5,Final Results: +/1 +@5,============== +/3 +@51,Parameter Estimate Summary +/2 +@5,Phase ++6,Parameter ++3,Label ++39,Estimate ++7,Std error ++13,Z ++10,Prob>|Z| +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Early: ++2,E0 ++4, ++3, 0.9921098 ++3, 0.7504215 ++4, 1.322 ++6, 0.1861 +/1 +<3 +@5, ++2,AGE ++4,Age (months) at repair ++3, -0.0298945 ++3, 0.009322347 ++4, -3.207 ++6, 0.0013 +/1 +<3 +@5, ++2,STATUS ++4,Clinical status (NYHA I-V) ++3, 0.9797339 ++3, 0.1917858 ++4, 5.108 ++4, <.0001 +/1 +<3 +@5, ++2,COM_IV ++4,Interventricular communication ++3, -3.14372 ++3, 0.400356 ++4, -7.852 ++4, <.0001 +/1 +<3 +@5, ++2,MAL ++4,Important associated cardiac anomaly ++3, 1.464631 ++3, 0.3094099 ++4, 4.734 ++4, <.0001 +/1 +<3 +@5, ++2,OPMOS ++4,Date of operation (months since 1/67) ++3, -0.0201961 ++3, 0.003839358 ++4, -5.260 ++4, <.0001 +/1 +<3 +@5, ++2,OP_AGE ++4, ++3,0.0001958949 ++3,5.953814E-05 ++4, 3.290 ++6, 0.0010 +/1 +@16,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Constant: ++2,C0 ++4, ++3, -9.3843 ++3, 1.404795 ++4, -6.680 ++4, <.0001 +/1 +<3 +@5, ++2,ORIFICE ++4,Accessory left AV valve orifice ++3, 2.672621 ++3, 0.9744226 ++4, 2.743 ++6, 0.0061 +/1 +<3 +@5, ++2,INC_SURG ++4,Surgical grade of AV valve incompetence ++3, 0.620517 ++3, 0.4245923 ++4, 1.461 ++6, 0.1439 +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<20 +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,Yes ++7, 0.1511909 +/1 +@55, (RHO ++19, 0.1511909 +;) +/1 +@43, +; +@55,NU +; ++6,Yes ++7, 1.438631 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 1 +/1 +@43, ++3,MUE ++6, ++7, 2.696918 +/1 +@55,------------------------------------ +/1 +@43,Constant: ++3,MUC ++6, ++7,8.403295E-05 +/1 +@43,------------------------------------------------ +/1 +$Note: Procedure HAZARD completed successfully. diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.meta new file mode 100644 index 0000000..429ebb1 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.1.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593516.2333820779.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:16Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.lst new file mode 100644 index 0000000..1e41e86 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.lst @@ -0,0 +1,371 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 310 ++1,observations available for analysis with: +/1 +@20, 70 ++1,events +/1 +@20, 240 ++1,Right Censored Observations +/1 +@20, 310 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup interval (months) after repair ++2, 0.001368954 ++3, 170.5826 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1, 240 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<7 +@5,Concomitant Information: +/1 +@5,======================== +/3 +@10,Phase ++5,Variable ++6,Label ++42,Mean ++11,Min ++10,Max +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +@10,Early: ++1,AGE ++6,Age (months) at repair ++2, 120.2347 ++2, 0.9199368 ++2, 790.9813 +/1 +@10, ++1,COM_IV ++6,Interventricular communication ++2, 0.5032258 ++2, 0 ++2, 1 +/1 +@10, ++1,MAL ++6,Important associated cardiac anomaly ++2, 0.2354839 ++2, 0 ++2, 1 +/1 +@10, ++1,OPMOS ++6,Date of operation (months since 1/67) ++2, 116.7377 ++2, 2.661246 ++2, 179.9462 +/1 +@10, ++1,OP_AGE ++6, ++2, 12632.69 ++2, 64.68025 ++2, 125813.4 +/1 +@10, ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@20,------------------------------------------------------------------------------------------------- +/1 +@10,Constant: ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@10, ++1,INC_SURG ++6,Surgical grade of AV valve incompetence ++2, 2.393443 ++2, 0 ++2, 5 +/1 +@10, ++1,ORIFICE ++6,Accessory left AV valve orifice ++2, 0.04516129 ++2, 0 ++2, 1 +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.1905077 ++2, 0.1905077 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -1.65806 +/1 +@21, ++1,(RHO ++23, 0.1905077 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1.437416 ++2, 1.437416 ++1, ++2,| ++2,E3 ++1,= Ln(|Nu|) +; ++2,Yes ++7, 0.3628471 +/1 +@11, +; +; ++1,M +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.3504743 ++2, 0.3504743 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes # ++7, -1.04847 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6,4.391673E-07 ++2,4.391673E-07 ++1,* ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -14.6384 +/1 +@11,-----------------------------------------------------------------------[hazard ERROR hzd_Error.c:29 hzd_Error_at] DLG1935 (errno=1) raised at hzd_ln_G1_and_SG1.c:43 in hzd_ln_G1_and_SG1() +HAZARD_ERROR_DLG1935 internal error in numerical core +-------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using an initial hessian matrix +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<6 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,E3 +@65,E0 +@79,AGE +@93,COM_IV +@107,MAL +@121,OPMOS +/1 +@37,OP_AGE +@51,STATUS +@65,C0 +@79,STATUS +@93,INC_SURG +@107,ORIFICE +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<2 +/1 +@5, 0 ++7, -201.962 +@34, -1.65806 +@48, 0.3628471 +@62, -1.04847 +@76, -0.0320577 +@90, 1.336675 +@104, 0.6872028 +@118, -0.0196338 +/1 +@34,0.0002086689 +@48, 0.5169533 +@62, -14.6384 +@76, 1.054988 +@90, 1.375285 +@104, 3.11765 +/1 +$Note: Procedure HAZARD completed successfully. diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.meta new file mode 100644 index 0000000..2c92ff0 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.2.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593516.51079598.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:16Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.lst new file mode 100644 index 0000000..1e41e86 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.lst @@ -0,0 +1,371 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 310 ++1,observations available for analysis with: +/1 +@20, 70 ++1,events +/1 +@20, 240 ++1,Right Censored Observations +/1 +@20, 310 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup interval (months) after repair ++2, 0.001368954 ++3, 170.5826 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1, 240 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<7 +@5,Concomitant Information: +/1 +@5,======================== +/3 +@10,Phase ++5,Variable ++6,Label ++42,Mean ++11,Min ++10,Max +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +@10,Early: ++1,AGE ++6,Age (months) at repair ++2, 120.2347 ++2, 0.9199368 ++2, 790.9813 +/1 +@10, ++1,COM_IV ++6,Interventricular communication ++2, 0.5032258 ++2, 0 ++2, 1 +/1 +@10, ++1,MAL ++6,Important associated cardiac anomaly ++2, 0.2354839 ++2, 0 ++2, 1 +/1 +@10, ++1,OPMOS ++6,Date of operation (months since 1/67) ++2, 116.7377 ++2, 2.661246 ++2, 179.9462 +/1 +@10, ++1,OP_AGE ++6, ++2, 12632.69 ++2, 64.68025 ++2, 125813.4 +/1 +@10, ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@20,------------------------------------------------------------------------------------------------- +/1 +@10,Constant: ++1,STATUS ++6,Clinical status (NYHA I-V) ++2, 2.235484 ++2, 1 ++2, 4 +/1 +@10, ++1,INC_SURG ++6,Surgical grade of AV valve incompetence ++2, 2.393443 ++2, 0 ++2, 5 +/1 +@10, ++1,ORIFICE ++6,Accessory left AV valve orifice ++2, 0.04516129 ++2, 0 ++2, 1 +/1 +@10,----------------------------------------------------------------------------------------------------------- +/1 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.1905077 ++2, 0.1905077 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -1.65806 +/1 +@21, ++1,(RHO ++23, 0.1905077 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1.437416 ++2, 1.437416 ++1, ++2,| ++2,E3 ++1,= Ln(|Nu|) +; ++2,Yes ++7, 0.3628471 +/1 +@11, +; +; ++1,M +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.3504743 ++2, 0.3504743 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes # ++7, -1.04847 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6,4.391673E-07 ++2,4.391673E-07 ++1,* ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -14.6384 +/1 +@11,-----------------------------------------------------------------------[hazard ERROR hzd_Error.c:29 hzd_Error_at] DLG1935 (errno=1) raised at hzd_ln_G1_and_SG1.c:43 in hzd_ln_G1_and_SG1() +HAZARD_ERROR_DLG1935 internal error in numerical core +-------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using an initial hessian matrix +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<6 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,E3 +@65,E0 +@79,AGE +@93,COM_IV +@107,MAL +@121,OPMOS +/1 +@37,OP_AGE +@51,STATUS +@65,C0 +@79,STATUS +@93,INC_SURG +@107,ORIFICE +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<2 +/1 +@5, 0 ++7, -201.962 +@34, -1.65806 +@48, 0.3628471 +@62, -1.04847 +@76, -0.0320577 +@90, 1.336675 +@104, 0.6872028 +@118, -0.0196338 +/1 +@34,0.0002086689 +@48, 0.5169533 +@62, -14.6384 +@76, 1.054988 +@90, 1.375285 +@104, 3.11765 +/1 +$Note: Procedure HAZARD completed successfully. diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.meta new file mode 100644 index 0000000..48b3193 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.1964531186.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.lst new file mode 100644 index 0000000..6ce6f0e --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.lst @@ -0,0 +1,716 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 5880 ++1,observations available for analysis with: +/1 +@20, 545 ++1,events +/1 +@20, 5335 ++1,Right Censored Observations +/1 +@20, 5880 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup Interval (months) After Repair ++2, 0.03285 ++3, 201.8276 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1,5335 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.2 ++2, 0.2 ++1, ++2,| ++2,E2 ++1, ++27,No +/1 +@21, ++1,(RHO ++23, 0.2 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E3 ++1, ++27,No +/1 +@11, +; +; ++1,M +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.02 ++2, 0.02 ++1, ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -3.91202 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6, 0.0008 ++2, 0.0008 ++1, ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -7.1309 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Late: +; +; ++1,TAU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L1 ++1, ++27,No +/1 +@11, +; +; ++1,GAMMA +; ++6, 3 ++2, 3 ++1, ++2,| ++2,L2 ++1, ++27,No +/1 +@11, +; +; ++1,ALPHA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L3 ++1, ++27,No +/1 +@11, +; +; ++1,ETA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L4 ++1, ++27,No +/1 +@11, +; ++1,MUL +; ++6, 1E-09 ++2, 1E-09 ++1, ++2,| ++2,L0 ++1,= Ln(muL) ++3,Yes ++7, -20.7233 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,| ++2,Late: ++4,| +@11,| ++8,Gamma*Eta = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Gamma*Eta/Alpha = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Weibull +; ++3,Yes ++13,| +/1 +@11,| ++8,Alpha>0, Generic equations 26 - 27 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;analytic ++1,derivatives +/1 +@21,initiated using the method of steepest +; descent +/2 +@7,Conservation of events: +@31,Not invoked +/1 +/2 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<4 +@5,Iteration ++3,Log Likelihood +@37,E0 +@51,C0 +@65,L0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<1 +@5, 0 ++7, -3719.46 +@34, -3.91202 +@48, -7.1309 +@62, -20.7233 +/1 +<1 +@5, 0 ++7, -3678.58 +@34, -3.82877 +@48, -6.81632 +@62, -20.6203 +/1 +<1 +@5, 0 ++7, -3588.74 +@34, -1.05643 +@48, -5.83943 +@62, -18.6926 +/1 +<1 +@5, 0 ++7, -3275.14 +@34, -0.00778063 +@48, -6.71312 +@62, -17.8643 +/1 +<1 +@5, 0 ++7, -3241.58 +@34, -0.457564 +@48, -6.94892 +@62, -17.0007 +/1 +<1 +@5, 0 ++7, -3236.08 +@34, -0.406988 +@48, -6.99933 +@62, -16.6576 +/1 +<1 +@5, 0 ++7, -3188.71 +@34, 0.02825802 +@48, -7.71306 +@62, -16.3828 +/1 +<1 +@5, 0 ++7, -3181.09 +@34, -0.0663316 +@48, -8.02175 +@62, -16.4938 +/1 +<1 +@5, 0 ++7, -3176.32 +@34, -0.0526804 +@48, -8.45212 +@62, -16.2028 +/1 +<1 +@5, 0 ++7, -3173.84 +@34, 0.07842258 +@48, -8.77685 +@62, -16.2328 +/1 +<1 +@5, 0 ++7, -3172.44 +@34, 0.02323703 +@48, -9.16601 +@62, -16.2149 +/1 +<1 +@5, 0 ++7, -3172.04 +@34, 0.05455968 +@48, -9.59732 +@62, -16.1551 +/1 +<1 +@5, 0 ++7, -3171.83 +@34, 0.06863245 +@48, -9.84814 +@62, -16.1777 +/1 +<1 +@5, 0 ++7, -3171.73 +@34, 0.06374836 +@48, -10.261 +@62, -16.1503 +/1 +<1 +@5, 0 ++7, -3171.71 +@34, 0.06881946 +@48, -10.5763 +@62, -16.1498 +/1 +<1 +@5, 0 ++7, -3171.7 +@34, 0.07200029 +@48, -10.81 +@62, -16.1434 +/1 +<1 +@5, 0 ++7, -3171.7 +@34, 0.07106515 +@48, -10.8906 +@62, -16.1438 +/1 +<1 +@5, 0 ++7, -3171.7 +@34, 0.07173708 +@48, -10.9324 +@62, -16.1431 +/1 +<1 +@5, 0 ++7, -3171.7 +@34, 0.0717147 +@48, -10.9352 +@62, -16.1431 +/1 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 38 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 3.643671 +/1 +@9,Number of events conserved = +; 545.0004 +/2 +@9,Log likelihood = +; -3171.7 +/2 +<2 +<15 +/2 +@5,Final Results: +/1 +@5,============== +/3 +@51,Parameter Estimate Summary +/2 +@5,Phase ++6,Parameter ++3,Label ++39,Estimate ++7,Std error ++13,Z ++10,Prob>|Z| +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Early: ++2,E0 ++4, ++3, 0.0717147 ++3, 0.07248483 ++4, 0.989 ++6, 0.3225 +/1 +@16,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Constant: ++2,C0 ++4, ++3, -10.9352 ++3, 4.001169 ++4, -2.733 ++6, 0.0063 +/1 +@16,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Late: ++2,L0 ++4, ++3, -16.1431 ++3, 0.08549196 ++4, -188.826 ++4, <.0001 +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<20 +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,Yes ++7, 0.2 +/1 +@55, (RHO ++19, 0.2 +;) +/1 +@43, +; +@55,NU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 1 +/1 +@43, ++3,MUE ++6, ++7, 1.074349 +/1 +@55,------------------------------------ +/1 +@43,Constant: ++3,MUC ++6, ++7,1.781956E-05 +/1 +@55,------------------------------------ +/1 +@43,Late: +; +@55,TAU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,GAMMA +; ++6,Yes ++7, 3 +/1 +@43, +; +@55,ALPHA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ETA +; ++6,Yes ++7, 1 +/1 +@43, ++3,MUL ++6, ++7,9.753089E-08 +/1 +@43,------------------------------------------------ +/1 +<11 +/2 +@49,Asymptotic Variance-Covariance Matrix +/2 +@24,E0 +@38,C0 +@52,L0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<5 +@5,Early: +/2 +@8,E0 +@21, 0.00525405 +@35, -0.113178 +@49, 0.001181044 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Constant: +/2 +@8,C0 +@21, -0.113178 +@35, 16.00936 +@49, -0.230987 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Late: +/2 +@8,L0 +@21, 0.001181044 +@35, -0.230987 +@49, 0.007308876 +/2 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<11 +/2 +@54,Asymptotic Correlation Matrix +/2 +@24,E0 +@38,C0 +@52,L0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<5 +@5,Early: +/2 +@8,E0 +@21, 1 +@35, -0.390236 +@49, 0.1905872 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Constant: +/2 +@8,C0 +@21, -0.390236 +@35, 1 +@49, -0.675265 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Late: +/2 +@8,L0 +@21, 0.1905872 +@35, -0.675265 +@49, 1 +/2 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +$Note: Procedure HAZARD completed successfully. diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.meta new file mode 100644 index 0000000..7b8dae0 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.deadp.KUL.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.173452946.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.lst new file mode 100644 index 0000000..60b04d4 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.lst @@ -0,0 +1,573 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 310 ++1,observations available for analysis with: +/1 +@20, 70 ++1,events +/1 +@20, 240 ++1,Right Censored Observations +/1 +@20, 310 ++1,Total Subjects +/2 +@38,Variable Label ++42,Min ++12,Max +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +@17,Time: ++3,INT_DEAD ++3,Followup interval (months) after repair ++2, 0.001368954 ++3, 170.5826 +/1 +@17,Event: ++3,DEAD ++3,Death ++2, 0 ++3, 1 +/1 +@17,----------------------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1, 240 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.1512095 ++2, 0.1512095 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -1.88909 +/1 +@21, ++1,(RHO ++23, 0.1512095 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1.438652 ++2, 1.438652 ++1, ++2,| ++2,E3 ++1,= Ln(|Nu|) +; ++2,Yes ++7, 0.3637066 +/1 +@11, +; +; ++1,M +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.2361727 ++2, 0.2361727 ++1, ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes # ++7, -1.44319 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Constant: +; ++1,MUC ++6,0.0005436977 ++2,0.0005436977 ++1,* ++2,| ++2,C0 ++1,= Ln(muC) ++3,Yes ++7, -7.51712 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Constant: ++38,| +/1 +@11,| ++8,Equations 24 - 25 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using the method of steepest +; descent +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<4 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,E3 +@65,E0 +@79,C0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<1 +@5, 0 ++7, -205.674 +@34, -1.88909 +@48, 0.3637066 +@62, -1.44319 +@76, -7.51712 +/1 +<1 +@5, 0 ++7, -183.38 +@34, -0.218635 +@48, 0.2224934 +@62, -1.30939 +@76, -8.06875 +/1 +<1 +@5, 0 ++7, -182.373 +@34, -0.451718 +@48, 0.239357 +@62, -1.30728 +@76, -8.41018 +/1 +<1 +@5, 0 ++7, -182.165 +@34, -0.706784 +@48, 0.1979728 +@62, -1.3336 +@76, -8.28454 +/1 +<1 +@5, 0 ++7, -181.946 +@34, -0.71249 +@48, 0.1483441 +@62, -1.33632 +@76, -8.31499 +/1 +<1 +@5, 0 ++7, -181.942 +@34, -0.732742 +@48, 0.144214 +@62, -1.33975 +@76, -8.27517 +/1 +<1 +@5, 0 ++7, -181.942 +@34, -0.730837 +@48, 0.1446039 +@62, -1.33969 +@76, -8.27342 +/1 +<1 +@5, 0 ++7, -181.942 +@34, -0.730812 +@48, 0.1446062 +@62, -1.33969 +@76, -8.27348 +/1 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 65 ++1,function evaluations +/1 +@9,Normal exit: Convergence attained +/1 +@9,Log base 10 of condition code = +; 1.768388 +/1 +@9,Number of events conserved = +; 70 +/2 +@9,Log likelihood = +; -181.942 +/2 +<2 +<15 +/2 +@5,Final Results: +/1 +@5,============== +/3 +@51,Parameter Estimate Summary +/2 +@5,Phase ++6,Parameter ++3,Label ++39,Estimate ++7,Std error ++13,Z ++10,Prob>|Z| +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Early: ++2,E2 ++4, ++3, -0.730812 ++4, . ++4, . ++5, . +; * +/1 +<3 +@5, ++2,E3 ++4, ++3, 0.1446062 ++4, . ++4, . ++5, . +; * +/1 +<3 +@5, ++2,E0 ++4, ++3, -1.33969 ++4, . ++4, . ++5, . +; * +/1 +@16,--------------------------------------------------------------------------------------------------------------------- +/1 +<3 +@5,Constant: ++2,C0 ++4, ++3, -8.27348 ++4, . ++4, . ++5, . +; * +/1 +@5,-------------------------------------------------------------------------------------------------------------------------------- +/1 +@5,* Negative second derivative indicating +; possible singularity. +/2 +<10 +/1 +@4,*-------------* +/1 +@4,| Termination | +/1 +@4,*-------------* +/2 +@5,Due to above singularity ++1, +/1 +$ERROR: Possible singularity detected...see listing below. +/2 +<20 +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,No ++7, 0.4815176 +/1 +@55, (RHO ++19, 0.4815176 +;) +/1 +@43, +; +@55,NU +; ++6,No ++7, 1.155584 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 1 +/1 +@43, ++3,MUE ++6, ++7, 0.2619274 +/1 +@55,------------------------------------ +/1 +@43,Constant: ++3,MUC ++6, ++7,0.0002551967 +/1 +@43,------------------------------------------------ +/1 +<11 +/2 +@49,Asymptotic Variance-Covariance Matrix +/2 +@24,E2 +@38,E3 +@52,E0 +@66,C0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<5 +@5,Early: +/2 +@8,E2 +@21, -0.730812 +@35, 0.1446062 +@49, -1.33969 +@63, -8.27348 +/2 +<5 +@8,E3 +@21, 10.09568 +@35, 0.3896216 +@49, 0.3875675 +@63, 0.3896216 +/2 +<5 +@8,E0 +@21, 1.925843 +@35, 0 +@49, 0 +@63, 0 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Constant: +/2 +@8,C0 +@21, 0 +@35, 0 +@49, 0 +@63, 0 +/2 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<11 +/2 +@54,Asymptotic Correlation Matrix +/2 +@24,E2 +@38,E3 +@52,E0 +@66,C0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<5 +@5,Early: +/2 +@8,E2 +@21, 1 +@35, 1 +@49, 1 +@63, 1 +/2 +<5 +@8,E3 +@21, -0.730837 +@35, 0.1446039 +@49, -8.27342 +@63, 0 +/2 +<5 +@8,E0 +@21, -0.730812 +@35, 0.1446062 +@49, -8.27348 +@63, 0 +/2 +<5 +@8,-------------------------------------------------------------------------------------------------------------------------- +/1 +@5,Constant: +/2 +@8,C0 +@21,-0.000299348 +@35,0.0006067473 +@49,0.0001749424 +@63, 0 +/2 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +!1 diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.meta new file mode 100644 index 0000000..3afb519 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.death.AVC.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.150447475.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.lst new file mode 100644 index 0000000..c4795d8 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.lst @@ -0,0 +1,485 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 382 ++1,observations available for analysis with: +/1 +@20, 44 ++1,events +/1 +@20, 338 ++1,Right Censored Observations +/1 +@27, 43 ++1,Left Censored Observations +/1 +@20, 382 ++1,Total Subjects +/2 +@1, 1 ++1,observation(s) found with inadmissable +; values +$Note: 1 observation(s) with inadmissible values. +/1 +@1, 1 ++1,total observations deleted +/1 +$Note: 1 total observation(s) deleted. +/2 +@63,Deleted Observations +/1 +@63,-------------------- +/1 +@62,Missing Inadmissable +/1 +@47,Variable ++7,Data ++6,Values ++12,Min ++12,Max +/1 +@26,--------------------------------------------------------------------------------------- +/1 +@26,Time: ++3,INT_TE ++6, 0 ++5, 0 ++9, 0.002737907 ++3, 248.3829 +/1 +@26,Event: ++3,TE ++6, 0 ++5, 0 ++9, 0 ++3, 1 +/1 +@26,Left Censored: ++3,STARTTME ++6, 0 ++5, 1 ++9, 0.002737907 ++3, 220.8834 +/1 +@26,Right Censored: ++3,CENSORED ++6, 0 ++5, 0 ++9, 0 ++3, 1 +/1 +@26,--------------------------------------------------------------------------------------- +/1 +/4 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.06 ++2, 0.06 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -2.81341 +/1 +@21, ++1,(RHO ++23, 0.1135311 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, -1.74 ++2, -1.74 ++1, ++2,| ++2,E3 ++1,= Ln(|Nu|) +; ++2,Yes ++7, 0.5538851 +/1 +@11, +; +; ++1,M +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.0174 ++2, 0.0174435 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -4.04879 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Late: +; +; ++1,TAU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L1 ++1, ++27,No +/1 +@11, +; +; ++1,GAMMA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L2 ++1, ++27,No +/1 +@11, +; +; ++1,ALPHA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L3 ++1, ++27,No +/1 +@11, +; +; ++1,ETA +; ++6, 1.32 ++2, 1.32 ++1, ++2,| ++2,L4 ++1,= Ln(Eta) +; ++2,Yes ++7, 0.2776317 +/1 +@11, +; ++1,MUL +; ++6, 0.000209 ++2,0.0002095225 ++1,* ++2,| ++2,L0 ++1,= Ln(muL) ++3,Yes # ++7, -8.47068 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M=0, Nu<0, Exponential equations 21 - 23 +; +;| +/1 +@11,| ++2,Late: ++4,| +@11,| ++8,Gamma*Eta = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Gamma*Eta/Alpha = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Weibull +; ++3,Yes ++13,| +/1 +@11,| ++8,Alpha>0, Generic equations 26 - 27 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using the method of steepest +; descent +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<4 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,E3 +@65,L4 +@79,E0 +@93,L0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<1 +@5, 0 ++7, -287.052 +@34, -2.81341 +@48, 0.5538851 +@62, 0.2776317 +@76, -4.04879 +@90, -8.47068 +/1 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 11 ++1,function evaluations +/1 +@9,Log base 10 of condition code = +; 2.240955 +/1 +@9,Number of events conserved = +; 44 +/2 +@9,Log likelihood = +; -270.892 +/2 +<10 +/1 +@4,*-------------* +/1 +@4,| Termination | +/1 +@4,*-------------* +/2 +@5,Internal sign violation, possibly data or ++1,specification dependent ++1,(SETCOE1200) +/1 +$ERROR: internal sign violation (SETCOE1200) +/2 +<20 +@5,Results at Termination: +/1 +@5,======================= +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,No ++7, 0.08860111 +/1 +@55, (RHO ++19, 0.1656029 +;) +/1 +@43, +; +@55,NU +; ++6,No ++7, -1.70648 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 0 +/1 +@43, ++3,MUE ++6, ++7, 3.97239E+20 +/1 +@55,------------------------------------ +/1 +@43,Late: +; +@55,TAU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,GAMMA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ALPHA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ETA +; ++6,No ++7, 1.219249 +/1 +@43, ++3,MUL ++6, ++7,0.0001583319 +/1 +@43,------------------------------------------------ +/1 +!1 diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.meta new file mode 100644 index 0000000..b53a85b --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.1274412004.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.lst new file mode 100644 index 0000000..dc0057c --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.lst @@ -0,0 +1,507 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 382 ++1,observations available for analysis with: +/1 +@20, 44 ++1,events +/1 +@20, 338 ++1,Right Censored Observations +/1 +@20, 382 ++1,Total Subjects +/2 +@1, 1 ++1,observation(s) found with inadmissable +; values +$Note: 1 observation(s) with inadmissible values. +/1 +@1, 1 ++1,total observations deleted +/1 +$Note: 1 total observation(s) deleted. +/2 +@63,Deleted Observations +/1 +@63,-------------------- +/1 +@62,Missing Inadmissable +/1 +@47,Variable ++7,Data ++6,Values ++12,Min ++12,Max +/1 +@26,--------------------------------------------------------------------------------------- +/1 +@26,Time: ++3,INT_TE ++6, 0 ++5, 1 ++9, 0.002737907 ++3, 247.6273 +/1 +@26,Event: ++3,TE ++6, 0 ++5, 0 ++9, 0 ++3, 1 +/1 +@26,--------------------------------------------------------------------------------------- +/1 +/1 +@4,*------* +/1 +@4,| Note | +/1 +@4,*------* +/2 +@7,in ++1, 339 ++1,observation(s) RCENSOR has been changed +; from 0 to 1 +/1 +$Note: RCENSOR has been changed from 0 to 1 in one or more observations. +/4 +<7 +@5,Concomitant Information: +/1 +@5,======================== +/3 +@31,Phase ++5,Variable ++11,Mean ++10,Min ++11,Max +/1 +@31,----------------------------------------------------------------- +/1 +@31,Late: ++1,NOPREVTE ++6, 0.1492147 ++2, 0 ++2, 3 +/1 +@31, ++1,NOTEE ++6, 1.427628 ++2, 1 ++2, 20.08554 +/1 +@31,----------------------------------------------------------------- +/1 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.05289487 ++2, 0.05289487 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -2.93945 +/1 +@21, ++1,(RHO ++23, 0.1000123 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, -1.73796 ++2, -1.73796 ++1, ++2,| ++2,E3 ++1,= Ln(|Nu|) +; ++2,Yes ++7, 0.5527149 +/1 +@11, +; +; ++1,M +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.01505178 ++2, 0.0170219 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -4.07325 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Late: +; +; ++1,TAU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L1 ++1, ++27,No +/1 +@11, +; +; ++1,GAMMA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L2 ++1, ++27,No +/1 +@11, +; +; ++1,ALPHA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L3 ++1, ++27,No +/1 +@11, +; +; ++1,ETA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L4 ++1, ++27,No +/1 +@11, +; ++1,MUL +; ++6,0.0009220701 ++2, 0.00104276 ++1,* ++2,| ++2,L0 ++1,= Ln(muL) ++3,Yes # ++7, -6.86588 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M=0, Nu<0, Exponential equations 21 - 23 +; +;| +/1 +@11,| ++2,Late: ++4,| +@11,| ++8,Gamma*Eta = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Gamma*Eta/Alpha = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Weibull +; ++3,Yes ++13,| +/1 +@11,| ++8,Alpha>0, Generic equations 26 - 27 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using an initial hessian matrix +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<4 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,E3 +@65,E0 +@79,L0 +@93,NOPREVTE +@107,NOTEE +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<1 +@5, 0 ++7, -306.404 +@34, -2.93945 +@48, 0.5527149 +@62, -4.07325 +@76, -6.86588 +@90, 2.653528 +@104, -0.368075 +/1 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 27 ++1,function evaluations +/1 +@9,Log base 10 of condition code = +; 2.29895 +/1 +@9,Number of events conserved = +; 44.00046 +/2 +@9,Log likelihood = +; -306.404 +/2 +<10 +/1 +@4,*-------------* +/1 +@4,| Termination | +/1 +@4,*-------------* +/2 +@5,Internal sign violation, possibly data or ++1,specification dependent ++1,(SETCOE1200) +/1 +$ERROR: internal sign violation (SETCOE1200) +/2 +<20 +@5,Results at Termination: +/1 +@5,======================= +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,No ++7, 0.281105 +/1 +@55, (RHO ++19, 0.470879 +;) +/1 +@43, +; +@55,NU +; ++6,No ++7, -1.40752 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 0 +/1 +@43, ++3,MUE ++6, ++7, 0.25778 +/1 +@55,------------------------------------ +/1 +@43,Late: +; +@55,TAU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,GAMMA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ALPHA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ETA +; ++6,Yes ++7, 1 +/1 +@43, ++3,MUL ++6, ++7, 0.001042768 +/1 +@43,------------------------------------------------ +/1 +!1 diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.meta new file mode 100644 index 0000000..5e0ed17 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.te123.OMC.renewal.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.1044316532.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst new file mode 100644 index 0000000..63ca247 --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst @@ -0,0 +1,496 @@ +$ +$Note: Procedure HAZARD (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +@26, T H R E E P H A S E P A R A M E T R I C H A Z A R D P R O C E D U R E +/2 +@5,Initial Summary: +/1 +@5,================ +/1 +<8 +/1 +@7,There are ++1, 382 ++1,observations available for analysis with: +/1 +@20, 44 ++1,events +/1 +@20, 338 ++1,Right Censored Observations +/1 +@27, 43 ++1,Left Censored Observations +/1 +@20, 382 ++1,Total Subjects +/2 +@1, 1 ++1,observation(s) found with inadmissable +; values +$Note: 1 observation(s) with inadmissible values. +/1 +@1, 1 ++1,total observations deleted +/1 +$Note: 1 total observation(s) deleted. +/2 +@63,Deleted Observations +/1 +@63,-------------------- +/1 +@62,Missing Inadmissable +/1 +@47,Variable ++7,Data ++6,Values ++12,Min ++12,Max +/1 +@26,--------------------------------------------------------------------------------------- +/1 +@26,Time: ++3,INT_TE ++6, 0 ++5, 0 ++9, 0.002737907 ++3, 248.3829 +/1 +@26,Event: ++3,TE ++6, 0 ++5, 0 ++9, 0 ++3, 1 +/1 +@26,Left Censored: ++3,STARTTME ++6, 0 ++5, 1 ++9, 0.002737907 ++3, 220.8834 +/1 +@26,Right Censored: ++3,CENSORED ++6, 0 ++5, 0 ++9, 0 ++3, 1 +/1 +@26,Weight: ++3,MORBID ++6, 0 ++5, 0 ++9, 0 ++3, 4 +/1 +@26,--------------------------------------------------------------------------------------- +/1 +/4 +<40 +/2 +@5,Model Specifications: +/1 +@5,===================== +/2 +@40,Initial Parameter Values +/1 +@40,------------------------ ++52,Starting +/1 +@11,Phase ++8,Parameter ++7,Specified ++8,Used ++7,| ++2,Theta ++26,Estimated? ++4,Value +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@11,Early: +; +; ++1,DELTA +; ++6, 0 ++2, 0 ++1, ++2,| ++2,E1 ++1, ++27,No +/1 +@11, +; +; ++1,THALF +; ++6, 0.0109 ++2, 0.0109 ++1, ++2,| ++2,E2 ++1,= Ln(Thalf) +; ++2,Yes ++7, -4.51899 +/1 +@21, ++1,(RHO ++23,7.555307E-09 +;) ++3,| +/1 +@11, +; +; ++1,NU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,E3 ++1, ++27,No +/1 +@11, +; +; ++1,M +; ++6, 1E-06 ++2, 1E-06 ++1, ++2,| ++2,E4 ++1, ++27,No +/1 +@11, +; ++1,MUE +; ++6, 0.018568 ++2, 0.01932156 ++1,* ++2,| ++2,E0 ++1,= Ln(muE) ++3,Yes ++7, -3.94653 +/1 +@24,------------------------------------------------------------------------------------------------------ +/1 +@11,Late: +; +; ++1,TAU +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L1 ++1, ++27,No +/1 +@11, +; +; ++1,GAMMA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L2 ++1, ++27,No +/1 +@11, +; +; ++1,ALPHA +; ++6, 1 ++2, 1 ++1, ++2,| ++2,L3 ++1, ++27,No +/1 +@11, +; +; ++1,ETA +; ++6, 1.4112 ++2, 1.4112 ++1, ++2,| ++2,L4 ++1,= Ln(Eta) +; ++2,Yes ++7, 0.3444404 +/1 +@11, +; ++1,MUL +; ++6, 0.0002495 ++2,0.0002596257 ++1,* ++2,| ++2,L0 ++1,= Ln(muL) ++3,Yes # ++7, -8.25627 +/1 +@11,------------------------------------------------------------------------------------------------------------------- +/1 +@5,# This MU parameter is estimated in closed +; form. +/1 +@5,* The value used is different from the +; value specified. +/1 +/1 +@5,Based on the values used, the following +; flags and equations have been set: +/1 +@11,* +;------------------------------------------------- +;* +/1 +@11,| ++2,Early: ++41,| +/1 +@11,| ++8,Delta = 0 +; ++3,Yes ++13,| +/1 +@11,| ++8,M*Nu = |1| +; ++3,No ++13,| +/1 +@11,| ++8,M>0, Nu>0, Generic equations 6 - 8 +; +;| +/1 +@11,| ++2,Late: ++4,| +@11,| ++8,Gamma*Eta = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Gamma*Eta/Alpha = 2 +; ++3,No ++13,| +/1 +@11,| ++8,Weibull +; ++3,Yes ++13,| +/1 +@11,| ++8,Alpha>0, Generic equations 26 - 27 +; +;| +/1 +@11,* +;------------------------------------------------- +;* +/1 +/2 +@5,Computational Methods: +/1 +@5,====================== +/2 +@7,Optimization: +;Quasi-Newton ++1,method using +;numeric ++1,derivatives +/1 +@21,initiated using the method of steepest +; descent +/2 +@7,Conservation of events: +@31,Invoked at each iteration +/1 +@7,If only one scaling parameter, +; estimation is in closed form. +/3 +<10 +@5,Results: +/1 +@5,======== +/2 +<15 +<4 +@5,Iteration ++3,Log Likelihood +@37,E2 +@51,L4 +@65,E0 +@79,L0 +/1 +@5,----------------------------------------------------------------------------------------------------------------------------- +/1 +<1 +@5, 0 ++7, -512.884 +@34, -4.51899 +@48, 0.3444404 +@62, -3.94653 +@76, -8.25627 +/1 +<1 +@5, 0 ++7, -453.644 +@34, -4.33707 +@48, 0.3396497 +@62, -1.87807 +@76, -9.17091 +/1 +<15 +/2 +@9,Optimization terminated after +; 0 ++1,iterations and +; 14 ++1,function evaluations +/1 +@9,Log base 10 of condition code = +; 2.665885 +/1 +@9,Number of events conserved = +; 37.18535 +/2 +@9,Log likelihood = +; -453.644 +/2 +<10 +/1 +@4,*-------------* +/1 +@4,| Termination | +/1 +@4,*-------------* +/2 +@5,Internal sign violation, possibly data or ++1,specification dependent ++1,(SETCOE1200) +/1 +$ERROR: internal sign violation (SETCOE1200) +/2 +<20 +@5,Results at Termination: +/1 +@5,======================= +/2 +@51,Estimates for Model Parameters +/2 +@43,Phase ++7,Parameter ++5,Fixed? ++5,Estimate +/1 +@43,------------------------------------------------ +/1 +@43,Early: +; +@55,DELTA +; ++6,Yes ++7, 0 +/1 +@43, +; +@55,THALF +; ++6,No ++7, 0.0372506 +/1 +@55, (RHO ++19,2.582016E-08 +;) +/1 +@43, +; +@55,NU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,M +; ++6,Yes ++7, 1E-06 +/1 +@43, ++3,MUE ++6, ++7, 0.3731403 +/1 +@55,------------------------------------ +/1 +@43,Late: +; +@55,TAU +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,GAMMA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ALPHA +; ++6,Yes ++7, 1 +/1 +@43, +; +@55,ETA +; ++6,No ++7, 1.398086 +/1 +@43, ++3,MUL ++6, ++7,0.0001040216 +/1 +@43,------------------------------------------------ +/1 +!1 diff --git a/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta new file mode 100644 index 0000000..6a9a23c --- /dev/null +++ b/tests/corpus/hazard/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593517.814321061.21222 +bin_kind=hazard +real_bin=hazard +real_exit=0 +argv= +timestamp=2026-05-12T13:45:17Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.lst new file mode 100644 index 0000000..b928fb6 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.lst @@ -0,0 +1 @@ +$ diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.meta new file mode 100644 index 0000000..698435a --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.1.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593518.3085822023.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:18Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.lst new file mode 100644 index 0000000..b928fb6 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.lst @@ -0,0 +1 @@ +$ diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.meta new file mode 100644 index 0000000..e753a9f --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hm.death.AVC.deciles.2.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593518.21503228.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:18Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.meta new file mode 100644 index 0000000..9f7d2bd --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm1.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593519.230481492.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:19Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.meta new file mode 100644 index 0000000..b9df447 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.hm2.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593519.2710815465.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:19Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.meta new file mode 100644 index 0000000..87aa2ad --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hp.death.AVC.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593519.3116829438.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:19Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.meta new file mode 100644 index 0000000..ca82ba2 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.1.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593520.1929827702.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:20Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.meta new file mode 100644 index 0000000..8090ef7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hs.death.AVC.hm1.2.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593520.233578907.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:20Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd= diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst new file mode 100644 index 0000000..1002ae7 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.lst @@ -0,0 +1,8 @@ +$ +$Note: Procedure HAZPRED (C-Version 4.4.6) +$ The Cleveland Clinic Foundation +$ 9500 Euclid Avenue +$ Cleveland, Ohio 44195 +$ Phone: (216) 444-6712 +$ Email: hazard@bio.ri.ccf.org +$Note: Procedure HAZPRED completed successfully. diff --git a/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta new file mode 100644 index 0000000..4f84f34 --- /dev/null +++ b/tests/corpus/hazpred/reference/v4.4.6-macos-arm64/hz.tm123.OMC.meta @@ -0,0 +1,10 @@ +# refresh-macos-corpus.sh metadata +uid=1778593520.2741722880.21222 +bin_kind=hazpred +real_bin=hazpred +real_exit=0 +argv= +timestamp=2026-05-12T13:45:20Z +host=Darwin 25.4.0 arm64 +tmpdir= +pwd=