diff --git a/pyproject.toml b/pyproject.toml
index d53ee72..bb9f2eb 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -31,7 +31,7 @@ keywords = [
 requires-python = ">=3.10"
 dynamic = ["version"]
 dependencies = [
-    "ga4gh.vrs>=2.1.3,<3.0",
+    "ga4gh.vrs>=2.2.0,<3.0",
     "ga4gh.cat_vrs~=0.7.1",
     "pydantic>=2.0,<3.0"
 ]