diff --git a/rust/lance-graph/src/ast.rs b/rust/lance-graph/src/ast.rs
index ff795c30..fa1c8cec 100644
--- a/rust/lance-graph/src/ast.rs
+++ b/rust/lance-graph/src/ast.rs
@@ -223,6 +223,10 @@ pub enum BooleanExpression {
         expression: ValueExpression,
         pattern: String,
     },
+    /// IS NULL pattern matching
+    IsNull(ValueExpression),
+    /// IS NOT NULL pattern matching
+    IsNotNull(ValueExpression),
 }
 
 /// Comparison operators
diff --git a/rust/lance-graph/src/parser.rs b/rust/lance-graph/src/parser.rs
index 813b4578..4d0f33ec 100644
--- a/rust/lance-graph/src/parser.rs
+++ b/rust/lance-graph/src/parser.rs
@@ -329,6 +329,14 @@ fn comparison_expression(input: &str) -> IResult<&str, BooleanExpression> {
             },
         ));
     }
+    // Match is null
+    if let Ok((rest, ())) = is_null_comparison(input) {
+        return Ok((rest, BooleanExpression::IsNull(left_clone)));
+    }
+    // Match is not null
+    if let Ok((rest, ())) = is_not_null_comparison(input) {
+        return Ok((rest, BooleanExpression::IsNotNull(left_clone)));
+    }
 
     let (input, operator) = comparison_operator(input)?;
     let (input, _) = multispace0(input)?;
@@ -476,6 +484,30 @@ fn return_item(input: &str) -> IResult<&str, ReturnItem> {
     ))
 }
 
+// Match IS NULL in WHERE clause
+fn is_null_comparison(input: &str) -> IResult<&str, ()> {
+    let (input, _) = multispace0(input)?;
+    let (input, _) = tag_no_case("IS")(input)?;
+    let (input, _) = multispace1(input)?;
+    let (input, _) = tag_no_case("NULL")(input)?;
+    let (input, _) = multispace0(input)?;
+
+    Ok((input, ()))
+}
+
+// Match IS NOT NULL in WHERE clause
+fn is_not_null_comparison(input: &str) -> IResult<&str, ()> {
+    let (input, _) = multispace0(input)?;
+    let (input, _) = tag_no_case("IS")(input)?;
+    let (input, _) = multispace1(input)?;
+    let (input, _) = tag_no_case("NOT")(input)?;
+    let (input, _) = multispace1(input)?;
+    let (input, _) = tag_no_case("NULL")(input)?;
+    let (input, _) = multispace0(input)?;
+
+    Ok((input, ()))
+}
+
 // Parse an ORDER BY clause
 fn order_by_clause(input: &str) -> IResult<&str, OrderByClause> {
     let (input, _) = multispace0(input)?;
@@ -828,6 +860,44 @@ mod tests {
         }
     }
 
+    #[test]
+    fn test_parse_query_with_is_null() {
+        let query = "MATCH (n:Person) WHERE n.age IS NULL RETURN n.name";
+        let result = parse_cypher_query(query).unwrap();
+
+        let where_clause = result.where_clause.expect("Expected WHERE clause");
+
+        match where_clause.expression {
+            BooleanExpression::IsNull(expr) => match expr {
+                ValueExpression::Property(prop_ref) => {
+                    assert_eq!(prop_ref.variable, "n");
+                    assert_eq!(prop_ref.property, "age");
+                }
+                _ => panic!("Expected property reference in IS NULL expression"),
+            },
+            other => panic!("Expected IS NULL expression, got {:?}", other),
+        }
+    }
+
+    #[test]
+    fn test_parse_query_with_is_not_null() {
+        let query = "MATCH (n:Person) WHERE n.age IS NOT NULL RETURN n.name";
+        let result = parse_cypher_query(query).unwrap();
+
+        let where_clause = result.where_clause.expect("Expected WHERE clause");
+
+        match where_clause.expression {
+            BooleanExpression::IsNotNull(expr) => match expr {
+                ValueExpression::Property(prop_ref) => {
+                    assert_eq!(prop_ref.variable, "n");
+                    assert_eq!(prop_ref.property, "age");
+                }
+                _ => panic!("Expected property reference in IS NOT NULL expression"),
+            },
+            other => panic!("Expected IS NOT NULL expression, got {:?}", other),
+        }
+    }
+
     #[test]
     fn test_parse_query_with_limit() {
         let query = "MATCH (n:Person) RETURN n.name LIMIT 10";
diff --git a/rust/lance-graph/src/semantic.rs b/rust/lance-graph/src/semantic.rs
index 10082042..b613fa69 100644
--- a/rust/lance-graph/src/semantic.rs
+++ b/rust/lance-graph/src/semantic.rs
@@ -247,6 +247,12 @@ impl SemanticAnalyzer {
             BooleanExpression::Like { expression, .. } => {
                 self.analyze_value_expression(expression)?;
             }
+            BooleanExpression::IsNull(expression) => {
+                self.analyze_value_expression(expression)?;
+            }
+            BooleanExpression::IsNotNull(expression) => {
+                self.analyze_value_expression(expression)?;
+            }
         }
         Ok(())
     }