diff --git a/packages/playwright-core/src/server/chromium/crPage.ts b/packages/playwright-core/src/server/chromium/crPage.ts
index 82139d2facac7..d126cb820a6a9 100644
--- a/packages/playwright-core/src/server/chromium/crPage.ts
+++ b/packages/playwright-core/src/server/chromium/crPage.ts
@@ -762,12 +762,13 @@ class FrameSession {
       return;
     }
 
-    // ... or an oopif.
-    const childFrameSession = this._crPage._sessions.get(event.targetId!);
+    // ... or an oopif / cross-process navigation.
+    const targetId = event.targetId!;
+    const childFrameSession = this._crPage._sessions.get(targetId);
     if (!childFrameSession)
       return;
 
-    // Usually, we get frameAttached in this session first and mark child as swappedIn.
+    // FIX PART 1: Synchronous early exit if already swapped
     if (childFrameSession._swappedIn) {
       childFrameSession.dispose();
       return;
@@ -777,11 +778,25 @@ class FrameSession {
     // In this case we don't know whether this is a remote frame detach,
     // or just a remote -> local transition. In the latter case, frameAttached
     // is already inflight, so let's make a safe roundtrip to ensure it arrives.
-    this._client.send('Page.enable').catch(e => null).then(() => {
-      // Child was not swapped in - that means frameAttached did not happen and
-      // this is remote detach rather than remote -> local swap.
-      if (!childFrameSession._swappedIn)
-        this._page.frameManager.frameDetached(event.targetId!);
+    this._client.send('Page.enable').catch(() => null).then(() => {
+      // FIX PART 2: Re-check _swappedIn after the microtask delay
+      if (childFrameSession._swappedIn) {
+        childFrameSession.dispose();
+        return;
+      }
+
+      // FIX PART 3: The core race-condition guard.
+      // If the session currently mapped to this targetId is NO LONGER 
+      // the childFrameSession that triggered this detachment, it means 
+      // a new session (from a cross-process navigation) has already 
+      // taken over this targetId. We must NOT call frameDetached.
+      if (this._crPage._sessions.get(targetId) !== childFrameSession) {
+        childFrameSession.dispose();
+        return;
+      }
+
+      // Safe to proceed with normal detachment
+      this._page.frameManager.frameDetached(targetId);
       childFrameSession.dispose();
     });
   }
diff --git a/tests/library/chromium/oopif.spec.ts b/tests/library/chromium/oopif.spec.ts
index a8971fe638a4c..24824c5665557 100644
--- a/tests/library/chromium/oopif.spec.ts
+++ b/tests/library/chromium/oopif.spec.ts
@@ -388,6 +388,34 @@ it('should allow to re-connect to OOPIFs with CDP when iframes were there alread
   await hostBrowser.close();
 });
 
+// @see https://github.com/microsoft/playwright/issues/41348
+it('should not throw TargetClosedException on cross-origin redirect after click', async ({ page, server }) => {
+  // 1. Set up a same-origin endpoint that 302 redirects to a cross-origin URL
+  server.setRedirect('/redirect', server.CROSS_PROCESS_PREFIX + '/target.html');
+  
+  // 2. Start on a same-origin page with a form
+  await page.goto(server.PREFIX + '/empty.html');
+  await page.setContent(`
+    <form action="${server.PREFIX}/redirect" method="POST">
+      <button type="submit">Submit</button>
+    </form>
+  `);
+  
+  // 3. Click the button. This triggers a POST -> 302 -> Cross-Origin Navigation.
+  // In Playwright 1.60, this specific sequence caused a race condition in 
+  // crPage.ts _onDetachedFromTarget, throwing TargetClosedException.
+  await Promise.all([
+    page.waitForNavigation(),
+    page.click('button'),
+  ]);
+  
+  // 4. Verify we successfully landed on the cross-origin page without crashing
+  expect(page.url()).toBe(server.CROSS_PROCESS_PREFIX + '/target.html');
+  
+  // 5. Ensure the page is still alive and functional
+  await page.evaluate(() => document.title);
+});
+
 async function assertOOPIFCount(browser: Browser, count: number) {
   if (browser.browserType().name() !== 'chromium')
     return;