diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt b/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
index ba2d827b..dee93f9c 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
@@ -46,7 +46,7 @@ packaging==26.2
 wrapt==2.2.1
 # test with the latest version of opentelemetry-api, sdk, semantic conventions, and instrumentation
 grpcio>=1.60.0; implementation_name != "pypy"
-grpcio<1.80.1; implementation_name == "pypy"
+grpcio<1.81.2; implementation_name == "pypy"
 
 -e util/opentelemetry-util-genai
 -e instrumentation/opentelemetry-instrumentation-genai-openai-agents