diff --git a/CHANGELOG.md b/CHANGELOG.md
index 64c0ea940f13..4de6bd1f2cad 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Ensure `@tailwindcss/oxide` falls back to WASM on platforms without native bindings ([#20383](https://github.com/tailwindlabs/tailwindcss/pull/20383))
 - Detect classes in Ruby percent literals using angle brackets or custom delimiters (e.g. `%w<flex>`, `%w|flex|`), including in Slim and Haml templates ([#20387](https://github.com/tailwindlabs/tailwindcss/pull/20387))
 - Preserve whitespace in `--default(…)` values in custom functional utilities (e.g. `--default(box alphabetic)` no longer becomes `boxalphabetic`) ([#20392](https://github.com/tailwindlabs/tailwindcss/pull/20392))
+- Ensure custom named `--spacing-*` theme values (e.g. `--spacing-none`) don't shadow keyword values of spacing utilities like `leading-none` ([#20394](https://github.com/tailwindlabs/tailwindcss/pull/20394))
 
 ## [4.3.3] - 2026-07-16
 
diff --git a/packages/tailwindcss/src/utilities.test.ts b/packages/tailwindcss/src/utilities.test.ts
index c9d4a5ff0dfa..1a46438e36af 100644
--- a/packages/tailwindcss/src/utilities.test.ts
+++ b/packages/tailwindcss/src/utilities.test.ts
@@ -25727,6 +25727,86 @@ test('leading', async () => {
     }
     "
   `)
+
+  // Custom named --spacing-* values should not shadow the none keyword but remain resolvable by name
+  expect(
+    await run(
+      ['leading-none', 'leading-big'],
+      css`
+        @theme {
+          --spacing-none: 0;
+          --spacing-big: 3rem;
+        }
+        @tailwind utilities;
+      `,
+    ),
+  ).toMatchInlineSnapshot(`
+    "
+    @layer properties {
+      @supports (((-webkit-hyphens: none)) and (not (margin-trim: inline))) or ((-moz-orient: inline) and (not (color: rgb(from red r g b)))) {
+        *, :before, :after, ::backdrop {
+          --tw-leading: initial;
+        }
+      }
+    }
+
+    :root, :host {
+      --spacing-big: 3rem;
+    }
+
+    .leading-big {
+      --tw-leading: var(--spacing-big);
+      line-height: var(--spacing-big);
+    }
+
+    .leading-none {
+      --tw-leading: 1;
+      line-height: 1;
+    }
+
+    @property --tw-leading {
+      syntax: "*";
+      inherits: false
+    }
+    "
+  `)
+
+  expect(
+    await run(
+      ['leading-none'],
+      css`
+        @theme {
+          --leading-none: 1.5;
+          --spacing-none: 0;
+        }
+        @tailwind utilities;
+      `,
+    ),
+  ).toMatchInlineSnapshot(`
+    "
+    @layer properties {
+      @supports (((-webkit-hyphens: none)) and (not (margin-trim: inline))) or ((-moz-orient: inline) and (not (color: rgb(from red r g b)))) {
+        *, :before, :after, ::backdrop {
+          --tw-leading: initial;
+        }
+      }
+    }
+
+    :root, :host {
+      --leading-none: 1.5;
+    }
+
+    .leading-none {
+      --tw-leading: var(--leading-none);
+      line-height: var(--leading-none);
+    }
+
+    @property --tw-leading {
+      syntax: "*";
+      inherits: false
+    }
+    "
+  `)
 })
 
 test('tracking', async () => {
diff --git a/packages/tailwindcss/src/utilities.ts b/packages/tailwindcss/src/utilities.ts
index 6c4a20cbc847..4c9192873a15 100644
--- a/packages/tailwindcss/src/utilities.ts
+++ b/packages/tailwindcss/src/utilities.ts
@@ -381,6 +381,7 @@ export function createUtilities(theme: Theme) {
     supportsNegative?: boolean
     supportsFractions?: boolean
     themeKeys?: ThemeKey[]
+    fallbackThemeKeys?: ThemeKey[]
     defaultValue?: string | null
     staticValues?: Record<string, AstNode[]>
     handleBareValue?: (value: NamedUtilityValue) => string | null
@@ -421,6 +422,19 @@ export function createUtilities(theme: Theme) {
             desc.themeKeys ?? [],
           )
 
+          if (value === null && desc.fallbackThemeKeys) {
+            // Static keywords like leading-none win over fallback namespaces like --spacing
+            if (!negative && desc.staticValues && !candidate.modifier) {
+              let fallback = desc.staticValues[candidate.value.value]
+              if (fallback) return fallback.map(cloneAstNode)
+            }
+
+            value = theme.resolve(
+              candidate.value.fraction ?? candidate.value.value,
+              desc.fallbackThemeKeys,
+            )
+          }
+
           // Automatically handle things like `w-1/2` without requiring `1/2` to
           // exist as a theme value.
           if (value === null && desc.supportsFractions && candidate.value.fraction) {
@@ -467,7 +481,7 @@ export function createUtilities(theme: Theme) {
     suggest(classRoot, () => [
       {
         supportsNegative: desc.supportsNegative,
-        valueThemeKeys: desc.themeKeys ?? [],
+        valueThemeKeys: [...(desc.themeKeys ?? []), ...(desc.fallbackThemeKeys ?? [])],
         hasDefaultValue: desc.defaultValue !== undefined && desc.defaultValue !== null,
         supportsFractions: desc.supportsFractions,
       },
@@ -543,8 +557,17 @@ export function createUtilities(theme: Theme) {
       utilities.static(`-${name}-px`, () => handle('-1px'))
     }
     utilities.static(`${name}-px`, () => handle('1px'))
+
+    // The generic `--spacing` namespace (and everything after it) is resolved
+    // only after `staticValues`, so custom values like `--spacing-none` don't
+    // shadow canonical keywords like `leading-none`.
+    let fallbackIndex = themeKeys.indexOf('--spacing')
+    let ownThemeKeys = fallbackIndex === -1 ? themeKeys : themeKeys.slice(0, fallbackIndex)
+    let fallbackThemeKeys = fallbackIndex === -1 ? undefined : themeKeys.slice(fallbackIndex)
+
     functionalUtility(name, {
-      themeKeys,
+      themeKeys: ownThemeKeys,
+      fallbackThemeKeys,
       supportsFractions,
       supportsNegative,
       defaultValue: null,