RXR-2394: lagtime updates #122
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roninsightrx
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Jul 8, 2025
roninsightrx
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Jul 8, 2025
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few comments
jasmineirx
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Jul 8, 2025
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in general looks good! a couple minor comments
Co-authored-by: Jasmine Hughes <43552465+jasmineirx@users.noreply.github.com>
Co-authored-by: Jasmine Hughes <43552465+jasmineirx@users.noreply.github.com>
jasmineirx
reviewed
Jul 9, 2025
| lagtime_ode <- attr(ode, "lagtime") | ||
| # override from ode if not specified by user and defined in ode | ||
| if(is.null(lagtime) && !is.null(lagtime_ode) && !lagtime_ode %in% c("NULL", "undefined")) { | ||
| if(is.null(lagtime) && !is.null(lagtime_ode) && lagtime_ode[1] != "NULL" && lagtime_ode[1] != "undefined") { |
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should this be a !any(lagtime_ode %in% c("NULL", "undefined"))
jasmineirx
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Jul 9, 2025
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Lagtime was previously handled by just adding the lagtime for a given compartment to each dose given into that compartment. So on the level of the event table created that was used as input for the simulation. However, this introduced the problem that the lagtime could not be estimated by PKPDmap (because it is essentially fixed).
To solve this, I moved the functionality that adapted the event table from happening before the core simulation into the core simulation function itself, right before the actual simulation. Now, this core function requires an additional lagtime parameter, which is then used to adapt the event table.
Related PR in PKPDmap