Standardized README to Markdown format

README.md

@@ -0,0 +1,84 @@
+# Dopaminergic (DA) Neuron Model with a Morphologically Realistic Dendritic Architecture
+
+The model captures several salient features of DA neurons under several pharmacological manipulations and exhibits depolarization block for sufficiently high current pulses into the soma.
+
+The model refers to the paper:
+
+Anna Y. Kuznetsova, Marco A. Huertas, Alexey S. Kuznetsov, Carlos A. Paladini and Carmen C. Canavier (2010) Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron  
+*J Comput Neurosci.* 2010 Jun;28(3):389-403.
+
+The files included here correspond to the morphologically realistic reconstructed model (see Figure 1 in paper) and reproduce results presented in the paper:
+
+1. `Fig2a2.hoc`  
+   Figure 2 (a2)
+
+2. `Fig2b2.hoc`  
+   Figure 2 (b2)
+
+3. `Fig2f2.hoc`  
+   Figure 2 (f2)
+
+4. `Fig6a_solid_trace`  
+   Figure 6a: solid line corresponding to 100 pA stimulation current
+
+5. `Fig6a_dashed-line_trace`  
+   Figure 6a: dashed line corresponding to 500 pA stimulation current
+
+The first three examples illustrate spontaneous firing of the model DA neuron in control (1) and after blocking SK channel (2) and Na channels (3).
+
+Last two files show the response of the model DA neuron to simulated current pulse to the soma for 100 pA (4) and 500 pA (5). In the last case one can observe depolarization block.
+
+You can run the simulation either by auto-launching from ModelDB, or by first compiling the mechanisms as follows:
+
+### a) Under LINUX  
+Type
+
+```
+nrnivmodl
+```
+
+Then type
+
+```
+nrngui mosinit.hoc
+```
+
+### b) Under Windows  
+Run `mknrndll` to compile the mod files in the top level directory.
+
+### c) Under MAC - OS X  
+Drag and drop the archive file on the `mknrndll` icon (in the NEURON application folder).
+
+---
+
+If running the individual files listed above:  
+Once Neuron has been started on your platform select in the main menu  
+`Tools -> RunControl`  
+`Graph -> Voltage axis`
+
+then select  
+`File -> load hoc`  
+and choose the file you want to run. Finally press **Init & Run**.
+
+---
+
+If auto-launched then press a button corresponding to the figure desired and you can generate figures like these:  
+
+**Fig 2a2:**  
+![screenshot 2a2](./screenshot2a2.jpg)
+
+**Fig 2b2:**  
+![screenshot 2b2](./screenshot2b2.jpg)
+
+**Fig 2f2:**  
+![screenshot 2f2](./screenshot2f2.jpg)
+
+**Fig 6a (solid trace):**  
+![screenshot 6a solid](./screenshot6a_s.jpg)
+
+**Fig 6a (dashed trace):**  
+![screenshot 6a dashed](./screenshot6a_d.jpg)
+
+---
+
+2025-06-02: Converted README to Markdown.