Standardized README to Markdown format

README.md

@@ -0,0 +1,23 @@
+# For the paper:
+
+Brette R. and Gerstner W. (2005), Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity, *J. Neurophysiol.* 94: 3637 - 3642.
+
+## Abstract:
+
+We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.
+
+A brian simulator model is available at this web page:
+
+[http://briansimulator.org/docs/examples-frompapers_Brette_Gerstner_2005.html](http://briansimulator.org/docs/examples-frompapers_Brette_Gerstner_2005.html)
+
+The default setting is the parameters of the regular spiking neuron model in table 1 in the paper (however other settings are available) and generates the following demo figure:
+
+![screenshot](./screenshot.png)
+
+This simulation requires Brian which can be downloaded and installed from the instructions available at [http://www.briansimulator.org/](http://www.briansimulator.org/)
+
+For support on installing and using Brian simulations there is a support group at [https://groups.google.com/group/briansupport](https://groups.google.com/group/briansupport).
+
+---
+
+2025-07-09: Converted README to Markdown.