SAIsim

Sexually Antagonistic Inversion Simulator

Purpose

This simulator models populations forward-in-time while tracking variants that confer survival and male reproductive benefit effects. It models paracentric inversions, and helps investigate how these selective effects contribute to the maintenance of inversion polymorphisms and the accumulation of sexually antagonistic variation.

Setup

Dependencies

• numpy

Installation

git clone git@github.com:csmcal/SAIsim.git

Condor Integration

SAIsim was developed at the University of Wisconsin-Madison and includes scripts for running simulations on the Center for High-Throughput Computing (CHTC) network using HTCondor distributed computing software.

Citation

If you use SAIsim in your research, please cite:

McAllester, C. S., & Pool, J. E. (2025). The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments. eLife.

License

This project is licensed under GPL3 - see the LICENSE file for details.