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2 changes: 1 addition & 1 deletion BUILD_NOTES_tch.txt
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Expand Up @@ -9,7 +9,7 @@ Then set the following environment variables:

export LIBTORCH={path/to/}libtorch
export DYLD_LIBRARY_PATH=${LIBTORCH}/lib
export LD_LIBRARY_PATH=${DYLD_LIBRARY_PATH}
export LD_LIBRARY_PATH="${LD_LIBRARY_PATH:+${LD_LIBRARY_PATH}:}${DYLD_LIBRARY_PATH}"

You can check that everything is working by running `modkit open-chromatin predict <args> --dryrun`.

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Binary file added docs/images/chromatin_stenciling_3_no_alpha.png
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2 changes: 1 addition & 1 deletion docs/intro_open_chromatin.html
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Expand Up @@ -180,7 +180,7 @@ <h1 class="menu-title">Modkit</h1>
<h1 id="find-regions-of-accessible-chromatin"><a class="header" href="#find-regions-of-accessible-chromatin">Find regions of accessible chromatin</a></h1>
<p>Nanopore sequencing can detect multiple base modifications simultaneously and we can leverage this capability by introducing exogenous base modifications at specific functional regions.
One such method uses a 6mA methyltransferase such as EcoGII or Hia5 to label accessible regions of chromatinized DNA, usually by treatment of cell nuclei with the enzyme.</p>
<p><img src="./images/chromatin_stenciling_3.png" title="Cartoon schematic showing exogenous 6mA introduced to regions of accessible chromatin" alt="Chromatin Accessibility treatment"></p>
<p><img src="./images/chromatin_stenciling_3_no_alpha.png" title="Cartoon schematic showing exogenous 6mA introduced to regions of accessible chromatin" alt="Chromatin Accessibility treatment"></p>
<h2 id="predict-regions-of-open-chromatin"><a class="header" href="#predict-regions-of-open-chromatin">Predict regions of open chromatin</a></h2>
<p>Modkit comes with a machine learning model that has been trained to identify regions of open chromatin based on 6mA signal.
You can invoke this model with the following command:</p>
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