Welcome to the official documentation for HumCFS, a manually curated database of human chromosomal fragile sites. Fragile sites are specific chromosomal regions susceptible to breakage under replication stress and are often involved in chromosomal rearrangements in tumors.
Web Server: http://webs.iiitd.edu.in/raghava/humcfs/
Kumar, R., Nagpal, G., Kumar, V., Usmani, S. S., Agrawal, P., & Raghava, G. P. S. (2019). HumCFS: a database of fragile sites in human chromosomes. BMC Genomics, 19(Suppl 9), 985. https://doi.org/10.1186/s12864-018-5330-5 zonedo:- (https://doi.org/10.5281/zenodo.20094980)
HumCFS provides a centralized resource for researchers studying genomic instability and its role in cancer and other diseases. The database categorizes fragile sites based on their frequency in the human population and provides detailed mapping and genetic annotations.
- Common Fragile Sites: Sensitive to replication stress and frequently rearranged in various cancers.
- Rare Fragile Sites: Archetypal trinucleotide repeats found in a small percentage of the population.
- Mapping Data: Provides precise chromosomal coordinates and cytobands for each fragile site.
- Chemical Inducers: Lists specific agents known to induce fragility at these sites.
- Gene Content: Identifies protein-coding genes located within or overlapping with fragile site regions.
- miRNA Association: Maps human miRNA genes present at fragile sites, facilitating studies on gene regulation and disease progression.
- Search Module: Allows users to query the database by chromosome, cytoband, or specific inducer.
- Browsing: Users can explore the database by fragile site type (Common or Rare).
HumCFS is built to provide high-quality, manually curated data for the bioinformatics community.
- Data Curation: Information is extracted from extensive literature reviews and cross-referenced with genomic databases.
- Genome Mapping: Coordinates are updated to align with current human genome assemblies.
- Interconnectivity: Entries include links to external resources for detailed gene and miRNA information.
- Cancer Research: Studying how fragile site rearrangements contribute to tumor development.
- Genomic Instability: Investigating the mechanisms of chromosomal breakage and repair.
- Diagnostics: Developing biomarkers for diseases associated with specific chromosomal breaks.
Prof. Gajendra P. S. Raghava Department of Computational Biology, Indraprastha Institute of Information Technology (IIIT-Delhi), New Delhi, India. Email: raghava@iiitd.ac.in
This resource is open-access and distributed under the terms of the Creative Commons Attribution License, permitting unrestricted use and distribution provided the original work is properly credited. This resource is open-access and distributed under the terms of the Creative Commons Attribution License, permitting unrestricted use and distribution provided the original work is properly credited.